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microglial cells

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New lipid nanoparticles effectively deliver RNA to microglia

14 December 2023 | By Drug Target Review

LNPs deliver small interfering RNA to the brain’s microglia to combat inflammation related to Alzheimer’s disease.

Brain organoids in detail: structural details of organoids (yellow and red) and organoid cells (blue and green)

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Incorporating microglia into brain organoids

16 November 2023 | By Drug Target Review

iPS-cell-derived microglia in brain organoids have enabled scientists to understand early brain development and microglia-associated disease.

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Huntington’s disease: a way to prevent cognitive decline

19 October 2023 | By Drug Target Review

Discovery about Huntington’s disease may apply to other neurodegenerative disorders, like Alzheimer’s and frontotemporal dementia.

neurons in purple surrounded by yellow protein aggregates - idea of Alzheimer's disease

news

Antibodies stimulate microglia to degrade Alzheimer’s amyloid plaques

11 March 2020 | By Hannah Balfour (Drug Target Review)

A novel antibody has been shown to stimulate microglia to degrade amyloid plaques in a murine model of Alzheimer’s disease.

MRI scan of a traumatic brain injury with affected area highlighted in red

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Depletion and repopulation of microglia could be a future therapy for TBI

26 February 2020 | By Hannah Balfour (Drug Target Review)

Researchers have shown that by effectively resetting the microglia, recovery of mice after a traumatic brain injury (TBI) was improved.

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L-serine could be used to treat ALS, after promising results in primate study

24 February 2020 | By Hannah Balfour (Drug Target Review)

Researchers have shown that, when treated with L-serine, a non-human primate model of ALS had fewer pathologies associated with the disease.

news

Short chain fatty acid supplementation could improve stroke recovery

3 January 2020 | By Victoria Rees (Drug Target Review)

Researchers have found that supplementing drinking water with short chain fatty acids helped mice to recover from stroke by increasing microglia activity.

news

Microglia critical for neurodegeneration in mice, study finds

14 October 2019 | By Victoria Rees (Drug Target Review)

Microglia brain immune cells are vital in conjunction with the APOE4 gene during the development of Alzheimer’s in mouse models, researchers have found.

news

Link between immune cells and Alzheimer’s discovered

21 August 2019 | By Victoria Rees (Drug Target Review)

Researchers have found that the presence of microglia brain cells allowed plaques to form in the brains of rodents, leading to Alzheimer’s disease.

news

Antibiotics weaken Alzheimer’s disease progression

21 July 2016 | By Niamh Louise Marriott, Digital Content Producer

Antibiotic treatment decreases levels of disease-causing plaques, a hallmark of Alzheimer's disease, according to a new study by neuroscientists...

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microglial cells