Molecular Biology

Bio-Techne

From fibroblasts to medicinal signalling cells: a paradigm shift in translational stem cell research

20 July 2018 | By Darius Widera, Jonathan Sheard, Thamil Selvee Ramasamy

Mesenchymal stem cells (MSCs) are fibroblast-like cells that give rise to mesenchymal derivatives including bone, fat and cartilage cells. In addition to the bone marrow, they can be readily obtained from adult vascularised peripheral tissues including adipose, olfactory, respiratory tissue, and peripheral blood.

Transforming translational research: CANscript^TM – a better predictive model for oncology

8 June 2018 | By Mark Paris

This webinar focused on a recent study evaluating a cohort of head and neck squamous cell carcinoma (HNSCC) patient tumours treated with anti-PD1 using CANscript™.

Supporting the progression of phenotypic hits with bioactivity profiling

4 June 2018 | By Drug Target Review

Bioactivity profiling has been traditionally used to assess the selectivity of new drug candidates in the context of target-based approaches, where pharmacological selectivity is a key requirement.

Transforming translational research: CANscript^TM – A better predictive model for oncology

27 April 2018 | By Mitra Biotech

In this webinar, speaker Mark Paris, PhD discussed a recent study evaluating a cohort of HNSCC patient tumours treated with anti-PD1 using CANscript TM;. He also be reviewed the results of this study as a means of investigating predictors of clinical response and identifying mechanisms of resistance.

Using bioactivity profiling to support the progression of phenotypic hits

27 April 2018 | By Eurofins Pharma Discovery Services

In this webinar, we discussed a recent case study where a phenotypic screen was performed using poly I:C / IL-4 stimulated human bronchial epithelial cells. This resulted in the identification of 7 representative hits which provided starting points for new drug discovery opportunities.

The European Life Sciences Community meets at BASEL LIFE

13 April 2018 | By BASEL Life Science

Leading experts of the European Life Sciences Community are engaging under the name BASEL LIFE to establish a bridge between science and business.

Mitra Biotech

The National Institutes of Health announce Biobanking Medical Project

9 April 2018 | By SMi Group

SMi Reports: The National Institutes of Health announce one of the most ambitious medical projects in biobanking, which will commence this spring.

Scientists discover new causes of cellular decline in prematurely aging children

21 March 2018 | By Drug Target Review

Researchers have uncovered new answers about why cells rapidly age in children with the rare and fatal disease, Hutchinson-Gilford Progeria Syndrome (HGPS).

Scientists develop novel method for membrane protein crystallisation

8 March 2018 | By Drug Target Review

Scientists in Switzerland have developed a new means of crystallising membrane proteins – a hitherto elusive feat – in order to study their structure and aid understanding of their processes.

Staphylococcus epidermidis may protect against skin cancer

2 March 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have reported a potential new role for some bacteria on the skin, protecting against cancer...

New insights into alpha-synuclein function holds promise for Parkinson’s treatment

19 February 2018 | By Drug Target Review

Researchers have gained important insights into the role of alpha-synuclein – the protein associated with Parkinson’s disease – in nerve cells and how calcium affects its function. This knowledge is hoped to better arm scientists regarding future treatment for the disease.

Study uncovers molecular events that reveal pathway toward heart disease therapy

14 February 2018 | By Drug Target Review

Scientists from UNC-Chapel Hill and Princeton University in the United States, reveal key molecular details that hold promise for ultimate goal of heart disease reversal.

Novel classification can lead to new ways to diagnose and treat cancer

14 February 2018 | By Drug Target Review

A novel approach to studying cancer has enabled researchers to group about 10,000 human cancers of 32 different types into 10 classes based on the molecular pathways that drive tumour growth.