news
CHRNA2 receptor proteins may help fat cells burn energy
The same proteins that moderate nicotine dependence in the brain may be involved in regulating metabolism by acting directly on certain types of fat cells...
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Protein
news
NMT molecule provides hope for common cold cure
Researchers have lab-tested a molecule that can combat the common cold virus by preventing it from hijacking human cells...
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Diabetes researchers find switch for fatty liver disease
Researchers have identified a key in the road for the way the liver deals with carbohydrates, fats and protein...
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Charles River Laboratories announces extended relationship with The Michael J. Fox Foundation
Extension includes new project to phenotype Parkinson’s disease models and the continuation of LRRK2 research.
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IL1RAP protein boosts multiple oncogenic pathways in AML
Researchers have discovered that a signalling protein elevated in patients with AML plays a much wider role in the disease than previously thought...
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Researchers uncover up to 100 potential drug targets for cancer
In a new study based on mouse cells, researchers have identified several new potential targets using state-of-the-art technology, many of which could be employed for future treatment of different types of cancers and diseases.
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New biomarker identified for early diagnosis of lung cancer
High levels of cytoskeleton-associated protein 4 (CKAP4) have been identified in the blood of patients with lung cancer.
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Diverse Parkinson’s-related disorders may stem from different strains of same protein
Researchers found that the type of brain cell afflicted in Parkinson’s-related brain disorders dictates which pathological form of α-synuclein (α-syn) protein becomes the disease culprit.
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Cambinol halts spread of toxic protein associated with Alzheimer’s progression
Research could help lead to the design of drugs that slow neurodegeneration...
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Study offers new approach to starve p53 deficient tumours
Sanford Prebys Medical Discovery Institute (SBP) researchers recently discovered an alternative metabolic pathway that might be used by cancer cells to survive nutrient deprivation.
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UFD1 protein responsible for aggressive leukaemia
Researchers have identified a protein critical for the aggressiveness of T-cell leukaemia...
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Double-bridged peptides bind any disease target
Researchers have developed a new peptide format that they call double-bridged peptides...
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Researchers develop new tools in the fight against diabetic blindness
A team of researchers led by the University of Missouri has employed a mouse model exhibiting diabetic retinopathy symptoms that could lead to future translational research studies.
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Obesity inhibits key cancer defence mechanism
Obesity could enhance cancer development while aspirin might prevent it - a new insight into potential targets for cancer prevention.
webinar
Using bioactivity profiling to support the progression of phenotypic hits
27 April 2018 | By Eurofins Pharma Discovery Services
In this webinar, we discussed a recent case study where a phenotypic screen was performed using poly I:C / IL-4 stimulated human bronchial epithelial cells. This resulted in the identification of 7 representative hits which provided starting points for new drug discovery opportunities.
