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Healing wounds with cell therapy
An experimental treatment in mice allows the reprogramming of blood cells in order to promote the healing process of cutaneous wounds...
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Protein
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Scientists identify protein linked to chronic heart failure
Researchers in Japan have identified a receptor protein on the surface of heart cells that promotes chronic heart failure.
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Flexible new method for early cancer diagnosis
Investments are now being made to roll out this innovation across healthcare and broaden the scope of the research in this field.
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Alzheimer’s, Parkinson’s, and Huntington’s diseases share common crucial feature
A study has found that abnormal proteins found in Alzheimer's disease, Parkinson's disease, and Huntington's disease all share a ability to cause damage...
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Protective responses appear weaker in neural stem cells from HD patients
A multi-institutional team based at Massachusetts General Hospital (MGH) has discovered how a potential treatment strategy for Huntington disease (HD) produces its effects, verified its action in human cells and identified a previously unknown deficit in neural stem cells from patients with HD.
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Antibodies as ‘messengers’ in the nervous system
Antibodies are able to activate human nerve cells within milliseconds and hence modify their function.
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DFG €66 million funding for 15 new research training groups
The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) is establishing 15 new Research Training Groups to further support early research...
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Plasma membrane protein may generate new neurons in the hippocampus
New research in suggests that the protein Efr3a regulates the BDNF-TrkB signaling pathway, which plays an important role in regulating learning and memory...
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BioPharmaSpec to expand in-house analytical capabilities
For characterising higher order protein structure and accurately defining CQAs of biopharmaceuticals...
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A new bioinformatics tool to decipher evolutionary biology
Understanding evolution is one of the cornerstones of biology - evolution is, in fact, the sole explanation for life's diversity on our planet. Based on the evolution of proteins, researchers may explain the emergence of new species and functions through genetic changes or how enzymes with novel functions might be…
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Scrib protein identified as a natural suppressor of liver cancer
A protein that typically helps keep cells organised and on task becomes a tumour suppressor in the face of liver cancer, scientists say.
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Shedding light on the brakes of Akt activity
Changes leading to the hyperactivation of the protein kinase Akt are observed in 50% of all tumours. Understanding Akt’s regulatory mechanisms is therefore essential for developing and improving cancer therapies....
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Scientists uncover mechanism allowing bacteria to survive the human immune system
Researchers have uncovered molecular details of how pathogenic bacteria fight back against the human immune response to infection.
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Tuberculosis: Researchers uncover how bacteria burst our cells
Scientists unveil the complex molecular structure that causes lethal infections by Mycobacterium tuberculosis (Mtb). Their findings might have implications for potential therapies against antibiotic-resistant tuberculosis.
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Developability assessment of therapeutic antibodies
Developability assessment is a broad term covering the evaluation of potential therapeutic candidates’ drug-like properties, manufacturability and safety profile. It is important to carry out this assessment as early as possible in the pre-clinical stage development to select the candidate with the most stable profile. This can minimise the risks…
