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Largest sequencing study of SARS-CoV-2 presents six separate strains
Researchers have sequenced SARS-CoV-2, revealing at least six strains with little variability, useful information for vaccine developers.
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Research & Development
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Drug candidate for memory loss associated with Alzheimer’s developed
A drug called CMS121 given to mice with Alzheimer's-like disease treated their memory loss, allowing them to perform the same as healthy control mice in tests.
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Decoy ACE2 receptors show promise as COVID-19 treatment in cell cultures
A new decoy receptor of ACE2 has been created which binds to and neutralises COVID-19 in live tissue cultures, preventing cells from becoming infected.
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Researchers develop first synthetic inhibitor of coagulation factor XII
A new FXII inhibitor has been developed that efficiently blocked coagulation in a thrombosis model without increasing the risk of bleeding.
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Coronavirus update: COVID-19 vaccine pre-clinical developments
Drug Target Review rounds up some of the latest news in COVID-19 vaccine candidate R&D.
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Protease inhibitors with antiviral activity against coronaviruses developed
Researchers have created compounds called 3C-like protease inhibitors which demonstrated antiviral activity against several coronaviruses in cells, including COVID-19.
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Near-identical protein on SARS and COVID-19 could be targeted by FDA-approved drugs
According to researchers, drugs that target envelope protein E on the SARS viral membrane could also be used to target a similar protein on COVID-19.
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Altering protein in C. elegans offers hope for anti-ageing drugs
Researchers have been able to manipulate the lifespans of C. elegans by altering the VRK-1 protein, offering a potential target hope for anti-ageing drugs.
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New set of channels between malaria parasite and blood cells discovered
A team has discovered channels that enable the transport of lipids between the malaria parasite and red blood cells during infection.
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Majority of T-cell targets not on COVID-19 Spike protein, study finds
Research has shown T cells taken from patients with COVID-19 target the same three to eight immunodominant epitopes - most of which are not on the Spike protein.
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Two compounds exhibit antibacterial properties against tuberculosis
Tested on two assays, researchers have shown that Redx03863 and Redx04739 can combat tuberculosis and do not lead to resistance.
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New insights into human and mouse genomes published in NIH study
The third phase of the ENCODE project has been released, with new information on genes and their potential regulators in their respective genomes.
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PLpro inhibitors support immune response to COVID-19 in cell cultures
Researchers have found that using GRL-0617, an PLpro inhibitor, in cell cultures blocked SARS-CoV-2 production and supported the cell immune response.
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Five developments in oncology targets
Drug Target Review explores some of the newest oncologic drug targets, including those for glioblastoma, lung cancer and breast cancer.
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Team suggest bradykinin system could be targeted by COVID-19 drugs
Researchers say computational analyses suggest the bradykinin system may explain some of the symptoms of COVID-19, providing a drug target.
