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ebook: Habitat for disease – disrupting the tumour micro-environment
No tumour prevails on its own. Rather, every tumour needs a community to thrive.
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RNAs
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Developing a COVID-19 testing kit using RNA detection
The developers of an RNA imaging technology are using it to create a COVID-19 coronavirus testing kit, able to recognise the viral genome.
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CRISPR RNA-targeted genetic screen could be used for COVID-19 therapy
A new Cas13 RNA screen has been used to establish guide RNAs for the COVID-19 coronavirus and human RNA segments which could be used in vaccines, therapeutics and diagnostics.
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Researchers create new Cas9 variant to reduce off-target CRISPR edits
A study has shown that altering amino acid residues in Cas9 to produce new variants can produce a vector with increased gene editing specificity.
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Mechanism of action revealed for remdesivir, potential coronavirus drug
Researchers have demonstrated how the drug known as remdesivir works, presenting the viral RNA polymerase of coronaviruses as a target for these conditions.
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New therapy stops seizures in mouse model of rare childhood epilepsy
A rare form of childhood epilepsy could be improved with a therapy called antisense oligonucleotide, following the development of a new model.
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Myc gene linked to alternative splicing changes in several cancers
A collaboration of academic institutions in the United States has identified a gene that is linked to alternative splicing changes that occur in several cancers.
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Key modifier identified in genetic deletion related to autism
A key modifier has been identified by researchers in a large fruit fly genetic deletion related to neurodevelopmental disorders such as schizophrenia and autism.
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RNA methylation knock-out mutant could be potential HMPV vaccine
Research has shown that human metapneumovirus uses RNA methylation to hide from the immune system and that knocking out this methylation creates a mutant strain which acts like a vaccine.
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DIRC3 tumour suppressor could be a new target for melanoma therapies
A study has shown that long non-coding RNA called DIRC3 can block melanoma growth and could be used to identify new targets for skin cancer therapies.
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Study paves way for new vaccines to protect infants against infections
An mRNA vaccine has been developed which has elicited strong immune responses in mice in the presence of maternal antibodies.
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RNA and machine learning: rational design for multidimensional biomarkers
Modern day oncology therapies have seen significant innovation in the last decade. It is high time we commit to using biomarkers that are driven by rational design and the latest computational methods.
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Scientists develop a new way to fight late-stage sepsis
Scientists have used nanotechnology to transform healthy immune cells into a drug with enhanced power to kill bacteria to help the immune system fight sepsis.
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RNA-targeting strategy can block Parkinson’s disease driver
A new drug-like compound has been developed which reportedly prevents the body from producing a protein that is often at the root of Parkinson's disease.
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microRNA could lead to new methods to treat multiple sclerosis
In a pre-clinical model of multiple sclerosis, orally treating susceptible mice with a microRNA from the diseased gut has prevented the disease.
