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UBR5 protein may reduce neurodegeneration in Huntington’s disease
Scientists have made an important step towards understanding the mechanisms that cause the neurodegenerative disorder Huntington's disease...
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Stem Cells
Stem cells are undifferentiated biological cells that can differentiate into specialised cells and can divide to produce more stem cells.
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From fibroblasts to medicinal signalling cells: a paradigm shift in translational stem cell research
Mesenchymal stem cells (MSCs) are fibroblast-like cells that give rise to mesenchymal derivatives including bone, fat and cartilage cells. In addition to the bone marrow, they can be readily obtained from adult vascularised peripheral tissues including adipose, olfactory, respiratory tissue, and peripheral blood.
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Urine-derived stem cells as innovative platform for drug testing and disease modelling
Kidneys are crucial for filtration of drugs and toxins and their proper function is essential for overall health. Unfortunately, due to disease and improper function, kidney transplantation or dialysis are necessary for millions of patients annually all over the world.1,2
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Whitepaper: A guide to achieving better insight with accurate data
In today’s modern world, data is everywhere. This eBook will guide you through the steps of how to achieve more with accurate data.
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Whitepaper: Opportunities in preclinical development
This whitepaper explains how you can find ways to optimise the holistic preclinical development process...
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CRISPRa used to reprogramme skin cells into pluripotent stem cells
Researchers have now for the first time succeeded in converting skin cells into pluripotent stem cells by activating the cell's own genes...
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Stem cells restore function in primate heart-failure study
Results suggest an approach that could be tested for treating people with heart failure...
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CRISPR technology may improve accuracy of predicting heart disease risk
Scientists may now be able to predict whether carrying a specific genetic variant increases a person's risk for disease using gene editing and stem cell technologies...
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Expert view: It’s an exciting time for the use of stem cells in research and the treatment of human disease
The Nobel Prize-winning observations and discoveries of John B. Gurdon and Shinya Yamanaka have ignited an explosion of excitement around the potential use of stem cells in research and treatment of human disease.
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ISSCR 2018 to highlight research driving new discoveries and advances in regenerative medicine
Progress in stem cell research and its translation to medicine is the focus of the International Society for Stem Cell Research annual meeting 20-23 June at the Melbourne Convention & Exhibition Centre in Melbourne, Australia.
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Automated assessment of liver and cardiac toxicities in lead optimisation
This webinar, supported by Tecan, focused on the automated assessment of liver and cardiac toxicities in lead optimisation, using biochemical and human iPS cell assays.
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Expert view: Overcoming the problems of working with human primary hepatocytes
Human primary hepatocytes (hpheps) are the gold standard for in vitro evaluation of drug metabolism, drug-drug interactions, and metabolic disease research. However, hpheps don’t survive in standard 2D culture for very long – no longer than two or three days.
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Application note: Cellartis® Power™ Primary HEP Medium – extend functionality of your primary hepatocytes to 4 weeks
Human primary hepatocytes (hphep cells) are the gold standard for in vitro evaluation of drug metabolism, drug-drug interactions, safety assessment of drug candidates, and disease modeling.
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The role of biomaterials in stem cell-based regenerative medicine
Despite their vast therapeutic potential in such areas as cell therapy and tissue engineering, stem cells have yet to live up to their original hype and demonstrate widespread clinical success.
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Blood stem cells balance the immune system by teamwork
The human body’s blood stem cells produce approximately 10 billion new white blood cells – termed immune cells – every day. Scientists in the U.S. have now discovered that some blood stem cells pick up the slack should any others fail to achieve these levels.
