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Stem cells are undifferentiated biological cells that can differentiate into specialised cells and can divide to produce more stem cells.
This webinar, supported by Tecan, focused on the automated assessment of liver and cardiac toxicities in lead optimisation, using biochemical and human iPS cell assays.
Human primary hepatocytes (hpheps) are the gold standard for in vitro evaluation of drug metabolism, drug-drug interactions, and metabolic disease research. However, hpheps don’t survive in standard 2D culture for very long – no longer than two or three days.
Human primary hepatocytes (hphep cells) are the gold standard for in vitro evaluation of drug metabolism, drug-drug interactions, safety assessment of drug candidates, and disease modeling.
Despite their vast therapeutic potential in such areas as cell therapy and tissue engineering, stem cells have yet to live up to their original hype and demonstrate widespread clinical success.
The human body’s blood stem cells produce approximately 10 billion new white blood cells – termed immune cells – every day. Scientists in the U.S. have now discovered that some blood stem cells pick up the slack should any others fail to achieve these levels.
In this issue: urine-derived stem cells offer an innovative platform for drug testing and disease modelling, a paradigm shift in translational stem cell research, and the role of biomaterials in stem cell-based regenerative medicine.
In this issue: the positive impact of genomics on drug discovery, development and deployment, the confluence of biology and technology, and Artificial Intelligence: harnessing the potential to drive progress in drug discovery promises much for phenotypic drug discovery
An international team of scientists has discovered that one of the biggest hitters in the immune system, macrophages, provide a cradle for mammary stem cells...
A new technique that uses tiny elastic balls filled with fluorescent nanoparticles aims to expand the understanding of the mechanical forces that exist between cells...
Scientists have successfully overcome the persistent cell rejection that has hitherto plagued attempts to introduce neural stem cells to replace damaged tissue in pigs.
Scientists have developed a simple and robust approach for directly reprogramming mature skin cells into immature muscle cells...
Researchers in China have conducted a unique study investigating the long-term effects of stem cells to treat angiitis-induced critical limb ischemia (AICLI).
This whitepaper outlines how advances in real-time live-cell monitoring and analysis methods are addressing these changing needs.
NIH-funded study closes in on personalised drug testing for neurological disorders...
27 April 2018 | By TECAN
ABOUT THIS WEBINAR: In this two-part webinar, both automation of P450 (CYP) assays and the automatisation of cellular differentiation processes and compound testing using human induced pluripotent stem cells based assays was covered. Metabolism of drugs is a key factor in compound toxicity, and automated assays which monitor inhibition or…
