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Application note: Real-time detection of Gs and Gi Signalling in living cells

Posted: 20 June 2018 | | No comments yet

Genetically-encoded biosensors from Montana Molecular allow for detection of GPCR signalling…

G-protein coupled receptors (GPCRs) are predominant drug targets. Therefore, monitoring GPCR activity upon compound addition in a cellular context is required. To this end, Montana Molecular developed biosensors that detect G-protein-driven cAMP generation. The sensor consists of a specific cAMP binding domain and a fluorescent label. It changes its fluorescence intensity if the second messenger cAMP is bound.











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