Expert view: Analytical power tool opens upstream bioprocessing bottlenecks for better antibody screening

The Octet® systems provide broad applications in high throughput to help bispecific and multi-specific antibody discovery.

Bio-layer interferometry (BLI) has shown practicality and effectiveness in monitoring antibody-antigen interactions, as binding events are monitored directly in real-time and label-free. The use of this microfluidic-free technology has increased rapidly in the past decade and this trend is predicted to continue as the technology continues to gain widespread acceptance and diversifies its application base, for example, with the characterisation of bispecific antibodies.

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