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This article outlines new research from the University of Pennsylvania, concerning Yersinia pseudotuberculosis, a relative of the bacterial pathogen that causes plague by triggering the body’s immune system to form lesions in the intestines.
![A microscopy image of Leptospira bacteria [Credit: Wunder et al. (CC BY 4.0)].](https://www.drugtargetreview.com/wp-content/uploads/Leptospira-bacteria.jpg)
A single vaccination with a mutated Leptospira bacteria prevented rodent models from developing leptospirosis, the most fatal type of zoonotic disease worldwide.
![Wasp on a wooden platform [Credit: University of Pennsylvania].](https://www.drugtargetreview.com/wp-content/uploads/Vespula-lewisii-wasp-750x500.jpg)
![Wasp on a wooden platform [Credit: University of Pennsylvania].](https://www.drugtargetreview.com/wp-content/uploads/Vespula-lewisii-wasp-e1602594547599.jpg)
Altering the mastoparan-L (mast-L) peptide found in Vespula lewisii wasp venom, researchers created several novel antimicrobial molecules.
The team demonstrated that expression of Bach2 protein and reduced mTORC1 activity is necessary for germinal B cells to become memory B cells.
The developers of a temporary coating which adheres to the small intestine demonstrated it could be modified to deliver drugs, aid digestion and stop absorption of glucose.
Cryogenic electron microscopy revealed that the vitamin B12 transporter on Mycobacterium tuberculosis acts like a non-selective sluice, transporting both the vitamin and antibiotics.
Researchers have found that using antibiotics in combination with cannabidiol (CBD) enhanced their effect against Staphylococcus aureus bacteria.
Researchers have shown that CRISPR-Cas3 can successfully attack C. difficile in vitro and in mice, by causing DNA damage to the pathogen.
Scientists suggest competence-blocking, ‘anti-evolution’ drugs could be administered alongside antibiotics to prolong the period before bacterial resistance emerges.
A new monoclonal antibody has been discovered which disassociates bacterial biofilms and stops bacteria from entering into circulation has been tested in mice.
International collaboration has shown that compounds with metals in them show antibacterial activity against MRSA, E. coli and A. baumannii.
Researchers have studied how the human body responds to viral infection when already infected by fungi, offering insights into the immune system.
A novel highly activated form of T cells could be suppressed to treat autoimmune conditions and activated in treating bacterial infections.
Antimicrobial peptides were found to act against Gram-negative bacteria and certain fungi by working either together or by adding up their individual effects...
Researchers have paved the path towards redesigning antibiotics through the alteration of the peptide assembly involved in the process...
