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Succinate in cystic fibrosis lungs feeds deadly bacteria
Targeting a deadly bacteria's use of succinate in the lungs could control infection and improve the health of people with cystic fibrosis.
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Cystic fibrosis
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CRISPR-Cas used to edit cystic fibrosis gene mutations
A research team have used genome editing to correct two of the mutations that cause cystic fibrosis.
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Quorum-sensing inhibitors may improve treatments for cystic fibrosis patients
Researchers have identified a promising solution to improving treatments offered to patients with cystic fibrosis that could lead to the development of new personalised therapies...
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New biomarkers found for cystic fibrosis
Canadian researchers have identified several unknown chemicals that were consistently associated with babies who had cystic fibrosis (CF), including two different drug and environmental compounds the infants secreted in sweat at much lower concentration levels...
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Screening for genetic diseases & chromosomal defects with a single biopsy
Couples who are undergoing pre-implantation genetic diagnosis (PGD) in order to avoid transmission of inherited diseases, such as Duchenne muscular dystrophy or cystic fibrosis, should also have their embryos screened for abnormal numbers of chromosomes at the same time, say Italian researchers.
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Study shows potential of stem cell therapy to repair lung damage
A new study has found that stem cell therapy can reduce lung inflammation in an animal model of chronic obstructive pulmonary disease (COPD) and cystic fibrosis. Although, still at a pre-clinical stage, these findings have important potential implications for the future treatment of patients.
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Sound Pharmaceuticals receives $1.6 Million Award to treat CF-related tinnitus
Sound Pharmaceuticals has been awarded up to $1.6M from Cystic Fibrosis Foundation Therapeutics (CFFT), the non-profit drug discovery and development affiliate of the Cystic Fibrosis Foundation.
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Exploring the need for mutation-specific treatments in cystic fibrosis
Despite that over 1,900 mutations of the cystic fibrosis transmembrane conductance regulator cause cystic fibrosis, only two treatment options exist.
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Personalised Medicines In-Depth Focus 2016
In this Personalised Medicines In-Depth Focus, Dr Adrian Harel talks about the importance of developing a diagnostic test and better treatments for traumatic brain injury. Plus, Caroline Richards, Editor of Drug Target Review explores the need for mutation specific treatments in cystic fibrosis...
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Moderna discuss mRNA therapeutics in cystic fibrosis
22 July 2016 | By Victoria White, Digital Content Producer
Drug Target Review recently caught up with Lorence Kim, Chief Financial Officer of Moderna, to find out more about the company‘s collaboration with Vertex and using mRNA therapeutics to treat patients with cystic fibrosis...
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Vertex and Moderna to develop cystic fibrosis mRNA Therapeutics
6 July 2016 | By Victoria White, Digital Content Producer
Their collaboration will focus on the use of mRNA therapies to enable cells in the lungs to produce functional copies of the CFTR protein...
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New molecules could help in the fight to prevent cystic fibrosis
9 June 2016 | By Victoria White, Digital Content Producer
Researchers have identified new molecules that could help in the fight to prevent diseases caused by faulty ion channels, such as cystic fibrosis...
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XBP-1 pathway plays key role in CF airway inflammation
13 January 2016 | By Victoria White
Researchers have discovered that the XBP-1 pathway was implicated in the hyper-inflammatory response of cystic fibrosis alveolar macrophages...
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CFTR interacts with the wrong partners in cystic fibrosis
30 November 2015 | By Victoria White
By removing these interactions, the researchers partially restored the protein’s normal function. The findings suggest that therapies could one day treat the root cause of cystic fibrosis, not just the symptoms...
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Improved gene therapy shows promise in cystic fibrosis
16 November 2015 | By Victoria White
Scientists have reported an improved gene therapy treatment can cure mice with cystic fibrosis. Cell cultures also responded well to the treatment...