article
Drug Target Review’s top content picks from 2022
In this article, Drug Target Review’s Izzy Wood and Ria Kakkad share some of the most ground-breaking moments from drug discovery this year.
List view / Grid view
HIV
news
“Slow” vaccine delivery improves immune response to HIV
An experimental HIV vaccine, delivered as increasing doses over several days, led to long-lasting and diverse antibody production in monkeys.
article
Is an HIV vaccine on the horizon?
Researchers in the US have developed a potential HIV vaccine approach that aims to prompt the creation of broadly neutralising antibodies via mRNA.
news
How to select the best combination of antibodies to treat HIV
A new computer-based approach could help clinicians select the best combinations of broadly neutralising antibodies to treat HIV based on the virus’ genetics, while minimising the risk of the virus escaping treatment.
news
Study highlights the essential role of dendritic cells in immunotherapy
Researchers have discovered how immune system dendritic cells are key to maintaining and regulating response to immunotherapy.
news
New CRISPR gene-editing technology could lead to better treatments for HIV
Scientists at Northwestern Medicine have developed new techniques in human blood to pave potential paths towards a HIV cure.
news
Possible connection between HIV and tuberculosis revealed
A recent study has shown that antiretroviral therapy timing impacts the animal version of HIV and latent tuberculosis.
news
Experimental mRNA HIV vaccine shows promise in pre-clinical studies
A new potential mRNA vaccine that delivers instructions for making two key HIV proteins has been tested in mice and rhesus macaques.
article
Treating cancer patients with cancer anorexia-cachexia syndrome
In this article, Patrick Kendall, Scientific Advisor for Artelo Biosciences, outlines why future treatment of cancer anorexia-cachexia syndrome may lie with drugs in development offering a mechanistic approach.
news
Potent nanoparticle may help improve vaccines for HIV and other diseases
The new nanoparticle adjuvant improved antibody production following vaccination against HIV, diphtheria and influenza in mouse models.
news
Positive pre-clinical results for CRISPR-based HIV therapy
The CRISPR-based therapy called EBT-101 excised HIV proviral DNA from the genomes of different cells and tissues in human cells and mice.
news
Novel strategy successfully suppresses HIV infection in mice
A new method, called synapse for T-cell activation (synTac), can attack HIV-infected T cells and may be a new cure for HIV and other diseases.
news
Exosome-based approach reduces levels of HIV in mice
Scientists have used exosomes to deliver a novel protein that prevented HIV from replicating in the bone marrow, spleen and brain of mouse models.
news
Researchers engineer “mini” CRISPR genome editing system
Stanford researchers have developed a multi-purpose “mini” CRISPR system, called CasMINI, that may be easier to deliver into human cells.
article
“Noisy” gene expression may help improve stem cell therapies
Researchers have identified a process that amplifies changes in gene expression, which could be harnessed to accelerate stem cell differentiation.