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New mRNA delivery system effectively protects neurons in rats from ischemia
Researchers have shown that an mRNA delivery system can be used to produce the BDNF protein in rats to protect neurons from ischemia.
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Spikes from AstraZeneca COVID-19 vaccine resemble SARS-CoV-2 S proteins
Using cryo-electron microscopy, researchers have shown that the Spike (S) protein on cells exposed to the AstraZeneca vaccine is highly similar to the SARS-CoV-2 S protein.
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New single-cell transcriptomics method does not put cells under stress
Researchers have created a new single-cell transcriptomics approach that cryopreserves cells, limiting the stress they are put under.
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Dynamic model of SARS-CoV-2 S protein reveals vaccine targets
A model of the SARS-CoV-2 Spike protein surface has uncovered vulnerabilities that researchers say could inform the development of COVID-19 vaccines.
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Article: Multisystem inflammatory syndrome in children with COVID-19
Children with multisystem inflammatory syndrome have a unique immunological profile revealed by systems-level analyses.
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Alliance to create atlas of human genetic variants launched
The Atlas of Variant Effects Alliance will develop a map of human genetic variants to advance the understanding and treatment of disease.
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Novel Zika virus vaccine shows success in pre-clinical trials
A new VLP-based Zika virus vaccine is able to protect mice completely from infection, researchers have found.
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How RNA therapeutics can be used to treat retinitis pigmentosa
Sahm Nasseri discusses promising pre-clinical results of an RNA-based therapeutic developed to treat retinitis pigmentosa type 11.
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Gold nanoparticles designed to seek out and isolate human bone stem cells
A team has designed gold nanoparticles to reveal specific bone stem cells, which could lead to treatments for major bone fractures.
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Novel opioid could provide pain relief alternative to fentanyl
NFEPP, a new opioid, inhibited colon pain in mice with colitis but did not cause the side effects associated with use of fentanyl.
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Fighting HIV: could antibodies be the answer?
Although a cure for HIV continues to elude scientists, strategies to control the virus and immunise people are developing at rapid pace. Here, Drug Target Review’s Victoria Rees discusses why researchers are focusing on antibodies as approaches to combat HIV and highlights recent findings from two pre-clinical studies into how…
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Tumour cell vaccine strategy developed for neuroblastoma and melanoma
A combination of checkpoint and small molecule inhibitors showed success at targeting Myc oncogenes in mouse neuroblastoma and melanoma models.
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Immunosurveillance and the importance of CD4 T cells in developing cancer vaccines
In this article, Dr Lien Lybaert describes how the innate and adaptive immune system work together to produce an effective and durable antitumour response. She explains why the best strategy for personalised cancer therapy is therefore to identify major histocompatibility (MHC) binding epitopes to cover the full antigenic repertoire of…
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Glycolytic-pathway inhibition and CTLA-4 blockade to improve immuno-oncology
In this Q&A, Dr Taha Merghoub discusses how a combination of glycolytic-pathway inhibition and immune checkpoint blockade using anti-CTLA-4 in patients with highly glycolytic tumours could present a personalised approach for immuno-oncology.
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Developing a broadly neutralising antibody therapeutic to combat SARS-CoV-2
With the ongoing COVID-19 pandemic, new treatments continue to be urgently needed. One potential solution is antibody therapeutics, which can be used to neutralise the coronavirus and provide future immunity to patients. Here, Dr Laura Walker from Adagio Therapeutics discusses how antibodies can be used in the fight against Severe…
