Screening

Using machine learning to predict symptoms

2 January 2019 | By Iqra Farooq (Drug Target Review)

Machine learning could, in future, be the way that clinicians decide on particular courses of treatments for patients affected by cancer...

Application note: Rapidly isolate high-producing clones

21 December 2018 | By Sphere Fluidics Ltd.

Find out how to streamline Cell Line Development by identifying high-producing clones with monoclonality assurance in one day.

Sphere Fluidics Ltd.

Application note: GABA_A Receptors

11 December 2018 | By SB Drug Discovery

SB Drug Discovery shows the validation of fluorescence and automated electrophysiology assays designed to assess agonists, antagonists and allosteric modulators of these receptors, culminating in a high-throughput electrophysiology assay suited to assessing multiple GABAA receptor subtypes on a single assay plate.

Webinar highlights: Integrated fragment based approach reveals enzymatic inhibitors with potential therapeutic application

10 December 2018 | By NanoTemper Technologies

This webinar, held on 25 October 2018, presented the results from integrated fragment-based approaches for Indoleamine 2,3 dioxygenase 1 (IDO1), an enzyme widely recognised as a drug target for the development of immunotherapeutic small molecules in oncology, unveiling the first ligands able to modulate non-catalytic signalling.

Webinar highlights: Harmonising drug-target binding data analytics on a single platform

7 December 2018 | By PerkinElmer

Harmonising drug-target binding data analytics looks at building a single, integrated software platform for a future pharma research and development digital ecosystem. This webinar, sponsored by PerkinElmer, outlined the fundamentals of a design process where an experimental analytics data workflow was integrated into a more seamlessly interactive digital platform.

Webinar highlights: Recent advances in diagnostics and treatments – from small molecules to cellular therapies

7 December 2018 | By Bio-Techne

The webinar presented an overview of the pre-clinical milestones, the current status of the global drug pipeline and a description of a number of novel drugs undergoing clinical trials.

Prolonging antibiotic potency by differentiating between resilience and resistance

7 December 2018 | By Drug Target Review

Distinguishing whether bacteria are resistant to antibiotics or resilient to them is hugely important in determining the success of the treatment...

Expert view: Three-dimensional cell cultures as predictive tools in early drug discovery

6 December 2018 | By Leena Mol Thuruthippalli (Senior Product Manager – Protein & Cell Analysis at Thermo Fisher Scientific)

Three-dimensional cell cultures (spheroids, organoids) are becoming widely used as a new predictive tool in early drug discovery. The use of 3D cell cultures is believed to provide a more physiologically relevant response than monolayer (2D) cell cultures because they closely mimic the extracellular matrix and cell-cell interactions that occur…

Immunoassay developed to detect small molecules

6 December 2018 | By Drug Target Review

An immunoassay developed to analyse small molecules has shown 50 times greater accuracy than current systems of analytical techniques...

Pinpointing biopsies to detect and target cancer

6 December 2018 | By Drug Target Review

Software that overlays tumour information from MRI scans onto ultrasound images could help to highlight areas of concern, and to detect and target cancer...

Expert view: Challenges in drug discovery screening

6 December 2018 | By Steven Jarvis (Scientific Director - Global Strategic Accounts at Merck)

The basic premise of drug discovery screening necessitates that the biological assays upon which it depends can be performed in a reproducible manner. In addition, the techniques employed must generate results that are biologically relevant and actionable.

Imaging whole brains of mice using functional ultrasound

5 December 2018 | By Drug Target Review

Functional ultrasound imaging has been used by researchers to obtain high-quality, high-resolution images of whole brains of mice...

Webinar highlights: Cell-based and biochemical high-throughput screening in 1536-well plates

5 December 2018 | By BMG Labtech GmbH

The Small Molecule Screening Facility (SMSF) at the University of Wisconsin Madison is a comprehensive high-throughput screening (HTS) centre where researchers have investigated antibiotic-resistant bacterial infections and screening for protein-protein interactions using HTS methods.

Expert view: High-throughput screening – make an impact by removing barriers

5 December 2018 | By Michael Kowalski (Global Project Manager at Beckman Coulter)

For drug discovery and biomarker research, screening campaigns are employed to identify potential new treatments for diseases and to answer questions that remain unknown in the scientific community.