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Computational epitope map of SARS-CoV-2 Spike protein developed
Researchers have produced a computational simulation of the SARS-CoV-2 Spike protein, finding spots that glycans do not cover.
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ebook: Antibody Discovery – technology and techniques to boost development
The latest ebook from Sartorius takes an in-depth look at the technologies and techniques that have been integral to developing the antibody discovery workflow, featuring a host of expert articles, interviews and application notes.
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Team identifies paediatric acute myeloid leukaemia drug target
Researchers have found that the gene mesothelin can be targeted by new antibody-drug conjugates to treat acute myeloid leukaemia in children.
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Gene therapy in Alzheimer’s mouse model preserves learning and memory
A new gene therapy that introduced SynCav1 to the brains of Alzheimer's mouse models was shown to preserve neuronal and synaptic plasticity.
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Antibodies cover entirety of SARS-CoV-2 Spike protein, study shows
Researchers have found that over 80 percent of antibodies target sections of the SARS-CoV-2 Spike protein other than the RBD.
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MIS hormone shown to suppress ovarian follicle development
Researchers have shown how the MIS hormone can prevent ovulation in females, making it a potential new form of contraception.
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New 3D lung-on-a-chip model enables study of respiratory diseases
Scientists have developed a 3D lung-on-a-chip model of the distal lung and alveolar structures, enabling the study of COVID-19.
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ebook: Antibody detection for cancer research
Gain more insight into immune-tumor interactions and learn how antibody detection techniques like multiplexing is advancing immunotherapies.
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New developments in the research field of immuno-oncology
The exciting potential of immunotherapy for cancer treatment continues its exploration and here, Drug Target Review investigates three of the latest pre-clinical developments in immuno-oncology research.
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Article: Finding a (biomarker) needle in the haystack
Summary of a neurology publication by Alnylam Pharmaceuticals: large-scale protein screening identifies novel biomarker for onset and progression of lethal ATTRv amyloidosis.
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Avocado compound targets enzyme critical to leukaemia cell growth
The fat molecule avocatin B, found in avocados, was shown to inhibit VLCAD, an enzyme vital for leukaemia cell metabolism.
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Raman spectroscopy platform developed to characterise IDPs
Optical tweezers-coupled Raman spectroscopy has been used to reveal the structure of alpha-synuclein, an IDP linked to Parkinson's disease.
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Sanguinarine shows promise against triple-negative breast cancer
A new study in cell cultures has shown that the sanguinarine plant compound could be used to treat people with triple-negative breast cancer.
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Hepatitis C drugs shown to boost remdesivir’s activity against SARS-CoV-2
Four hepatitis C drugs have demonstrated promise as boosters to increase the efficacy of remdesivir against SARS-CoV-2 by as much as tenfold.
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Study points to treatment approaches for advanced small-cell lung cancer
Having sequenced samples of advanced small-cell lung cancer, researchers have identified patterns linked to resistance to certain therapies.
