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Application note: Kinetic quantification cell proliferation in live cells
Cell proliferation assays are a cornerstone of cancer therapeutic, developmental biology, and drug safety research.
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Cell organisation determined by new mathematical framework
US scientists, using high-resolution imaging, debuted a new way to see cell organisation and rich variation in cell shape
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Executive summary: Scale-up strategies for late-stage cell therapies
Discover how Catalent can help you achieve efficiencies and develop a robust, reproducible manufacturing plan for late-stage and commercial launch.
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Synthetic tissue helps restore and repair erectile function in animal models
Chinese scientists have developed a synthetic tissue that repairs penile injuries and restores normal erectile function in pigs.
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A promising oral drug delivery platform could replace injections with pills
The researchers explored the possibility of using the probiotic bacteria Lactobacillus reuteri as a novel oral drug delivery platform to treat rheumatoid arthritis in an animal model.
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50 year old blood pressure drug offers alternative treatment for PTSD
US scientists offer a new purpose for the blood pressure drug clonidine as a treatment to reduce the affects of PTSD.
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Poster: Antibodies for microglial activation states
Development of novel rabbit monoclonal antibodies to characterise microglial activation states in murine models of Alzheimer’s disease.
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Protein Grb10 offers a potential new approach for treating obesity
The researchers found that the protein Grb10 promotes leptin activity in the brain, opening the possibility of developing Grb10-based new approaches to treat obesity.
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Novel cancer vaccine simultaneously kills and prevents brain cancer
US researchers develop a dual-action cell therapy engineered to eliminate established tumours and train the immune system to eradicate primary tumour and prevent cancer’s recurrence.
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Application note: Dynamic quantification of cell migration in real time
Discover the Incucyte® Scratch Wound Analysis Software Module for automated image-based measurements of cell migration in vitro, using label-free analysis.
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The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes
The researchers argue hepatocytes are susceptible to SARS-CoV-2 pseudovirus infection and propose that metformin could be a therapeutic option to attenuate SARS-CoV-2 infection in patients with fatty liver.
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Life-saving approach may overcome persistent obstacles to cell transplantation and immunotherapy
In their study, researchers duped antibodies with a decoy to prevent rejection of transplanted cells.
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When exhausted, cancer-fighting T cells may switch sides
Using flow cytometry, Dr Greg Delgoffe and Dr Paolo Vignali highlight that low oxygen environment of tumours can prompt exhausted T cells to suppress the immune system instead of combating cancer.
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Researchers generate organoid model for gastroesophageal junction cancer
The scientists discovered that dual knockout of genes in organoids grown from human tissue can generate a model of a potential therapeutic target for gastroesophageal junction cancer.
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Latest developments in COVID-19 research
As COVID-19 continues to evolve, researchers are still on the lookout for new ways to protect against the virus. Drug Target Review brings you some of the most recent pre-clinical developments.
