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Chemokines work undercover as drivers of autoimmune disease
New research has uncovered a hitherto unknown mechanism whereby chemokines form DNA-bound nanoparticles that play a key role in autoimmune disorders.
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Video: Did you know that ddPCR technology offers lower variability for viral titer determination?
Droplet Digital PCR (ddPCR) offers greater accuracy and precision in quantifying viral titer in gene therapies.
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ELRIG: New modalities in pharmacology and drug discovery
Drug Target Review’s Ria Kakkad recently visited ELRIG and the British Pharmacological Society’s conference on New Modalities in Pharmacology and Drug Discovery which took place in London, UK. This article shares some of the key takeaways from the event.
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How the innate immune system detects HIV-1
Researchers have found that the innate immune system requires two steps to defend against HIV-1, even when the virus is present in small amounts.
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Discovered receptor that could alleviate the need for chemotherapy
Researchers have shown that a synthetic IL-9 receptor allows T cells to fight against cancer without the need for chemotherapy or radiation.
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New insight into the key properties of an antibody needed to fight cancer
The findings have enabled researchers to design antibodies to activate important receptors on immune cells and deliver more powerful anti-cancer effects.
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Visualising mRNA molecules in the brains of living mice
Scientists have developed a new imaging technique that allows researchers to see gene expression and mRNA molecules in the brains of live mice in real time.
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Using organoids to identify drugs for autosomal dominant polycystic kidney disease
Scientists generated kidney organoids and used them to identify potential drugs to treat autosomal dominant polycystic kidney disease.
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Scientists discover the key to hepatitis A virus replication
With no current treatments for hepatitis A, scientists have discovered how a protein and enzymes interact to allow hepatitis A virus to replicate.
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Dominant Omicron subvariants better at evading vaccines and antibody treatments
A new study has found that the latest Omicron subvariants are even better at avoiding vaccines and most antibody treatments than previous variants.
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How EGF receptors influence cell growth
A new insight into the way the EGF receptor sends signals into cells could help researchers design new cancer drugs that target this protein.
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New immune targets to improve survival from sepsis
In a pre-clinical study, researchers from the US set out to develop a treatment for sepsis. Here, Daniel Morales-Mantilla, Dr Robin Parihar and Dr Katherine King, from Baylor College of Medicine, describe how they utilised haematopoietic stem and progenitor cell infusion to improve the survival of mice from sepsis.
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Using cortical spheroids to study endocannabinoids and autism spectrum disorder
The endocannabinoid system may play a role in the development of autism spectrum disorder and might be key to treating people with severe forms of the condition. In this commentary, Dr Karen Litwa, Assistant Professor at East Carolina University’s Brody School of Medicine, US explores how a bioelectronic assay is…
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Soft nickases could be the future of safe, effective gene editing
Researchers in the US have developed a new CRISPR method for treating genetic conditions using nickases that they say is safer and more effective.
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Key protein identified that helps turn pancreatic cancer cells into a more aggressive form
A new study has shown that it is possible to reverse key process that allows pancreatic cancer cells to grow and spread around the body.
