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Interferon pathway could provide drug target for cancers

A study has found that signals from interferons can be blocked, allowing the immune system to attack tumours which provides a potential target.

New research has discovered that a crucial signalling pathway which tells the immune system to combat tumours can also be used by cancer cells to inhibit the immune system. According to the researchers, the findings can be used to improve cancer therapies.

The research was conducted by the Abramson Cancer Centre at the University of Pennsylvania. The team investigated the interferon (IFN) signalling pathway, which usually helps activate the immune system to protect cells from viruses. However, IFNs can also block this system.

“This paradoxical effect has been seen in other diseases – such as chronic viral infections – but our study shows how cancer cells take advantage of the suppressive properties of IFNs to interfere with cancer immunotherapy,” said the study’s senior author Dr Andy Minn.

IFN signaling exists in the majority of human cancers, so this could end up applying more broadly

The researchers observed that when IFNs halt the immune system, cancer cells intercept and manipulate the process.

When the IFN signal is stronger in cancer cells, there could be a therapeutic solution. Blocking the signal from tumours would allow the immune system to attack the cancer. In pre-clinical models of melanoma, breast and colorectal cancer, the researchers found they were able to inhibit the signals.

“IFN signaling exists in the majority of human cancers, so this could end up applying more broadly,” Minn said.

The researchers say the next step is to identify methods of making IFN signals stronger for use in therapies.

The findings were published in Cell.

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