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No-cut CRISPR could be used to treat muscular dystrophy
Researchers have successfully used a no-cut CRISPR gene editing technique as a therapy for muscular dystrophy in mice models.
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Wellcome Trust Sanger Institute
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Inhibiting METTL3 destroys AML cells without harming normal blood cells
An unexpected drug target for acute myeloid leukaemia could open new avenues to develop effective treatments against the potentially lethal disease...
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Five new malaria targets that could lead to an effective vaccine
Scientists have identified five targets that reduce the parasite's ability to invade red blood cells...
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Stem cell line offers expanded potential for research and treatments
Researchers have created Expanded Potential Stem Cells that have greater potential for embryonic development than current stem cell lines...
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Genome editing reveals a role for OCT4 in human embryogenesis
Researchers have used genome editing technology to reveal the role of a key gene in human embryos in the first few days of development...
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How next-generation sequencing is opening the door for drug discovery
The Wellcome Trust Sanger Institute's Kim Judge explains how Next Generation Sequencing forms a crucial part of the scientist’s toolkit and makes a valuable contribution to the field of drug discovery...
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New genetic analysis reveals early diagnosis for breast cancer
Researchers have shown that catching and treating breast cancer before it spreads is now a realistic goal...
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New drug targets identified to defend against chlamydia infections using CRISPR and stem cells
Human induced pluripotent stem cell derived macrophages (iPSDMs) provide a cell-based model system to study chlamydia infection in the laboratory. Amy Yeung from Wellcome Trust Sanger Institute explains how she used this model in combination with CRISPR-Cas 9 technology to explore the potential of the two genes, IRF5 and IL10RA,…
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Targets In-Depth Focus 2017
Included in this Targets In-Depth Focus: Intracellular target validation in cellular systems; New drug targets identified to defend against chlamydia infections using CRISPR and stem cells; Novel solutions for tough targets with real bite...
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Human Cell Atlas data platform kicks off with support from CZI
The Chan Zuckerberg Initiative announced financial support for the Human Cell Atlas, which uses sequencing technology to redefine every cell in the body...
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New chlamydia drug targets discovered using CRISPR and stem cells
Scientists have created an innovative technique for studying how chlamydia interacts with the human immune system...
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Novel genes identified that help suppress prostate and other cancers
New genes which help prevent prostate, skin and breast cancer development in mice have been discovered by researchers at the Wellcome Trust Sanger Institute and their collaborators.
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£100 million for Cancer Research’s ‘grand challenge’ competition winners
Cancer Research UK announced that four international teams are the first recipients of its global £100m Grand Challenge competition, which aims to overcome the biggest challenges facing cancer researchers in a global effort to beat cancer sooner.
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Enhanced CRISPR allows exploration of disease in every cell type
2 December 2016 | By Niamh Louise Marriott, Digital Editor
These systems will allow researchers worldwide to rapidly and accurately explore the changing role of genes as the cells develop into tissues...
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Newly discovered protein may hold key to better drugs for neglected diseases
3 November 2016 | By Niamh Louise Marriott, Digital Content Producer
Bicyclic nitro-drugs used in the treatment of tuberculosis, including the recently approved drug delamanid, were reported as promising fast track options...