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Blood test predicts the best treatment for prostrate cancer
The study showed that patients testing positive for AR-V7 responded better to taxane-based chemotherapy and negative to hormone-targeted therapy...
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Analytical Techniques
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Adapting drug discovery to Artificial Intelligence
Drug discovery has always been challenging; today, more so than ever. While there has been success in addressing many diseases, others remain intractable...
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Improving the translation of disease biology though phenomics
How times change. Up to 15 years ago, you would be hard-pressed to find a drug discovery conference with a track dedicated to phenotypic approaches. The underpinning science was called high-content imaging or analysis, being mainly confined to academic drug discovery labs and a handful of pioneers in industry. but…
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Urine tests are important in diagnosing myeloma
It may be better to examine the urine and the blood of patients suspected of tumours of the plasma cells...
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pGENMi predicts genomic features associated with drug responses
A new system, pGENMi, could predict genomic features associated with drug responses, by identifying differences in gene expression...
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Discovery of statistical method identifies cancer predisposition
New statistical method, ALFRED, could identify predisposition for cancers by using cancer genome data sets to identify risk variants.
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Product hub: The Thermo Scientific™ CellInsight™ CX7 LZR High Content Analysis System
Introducing the Thermo Scientific™ CellInsight™ CX7 LZR High Content Analysis System: the only imaging and analysis platform for advanced performance in screening and analysis.
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Expert view: High-throughput binding kinetic analysis – is it the new frontier in drug discovery?
Sometimes the difference between identifying a partial or super agonist is only the time point at which the binding reaction is measured.
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Stem Cells In-Depth Focus 2018
In this issue: urine-derived stem cells offer an innovative platform for drug testing and disease modelling, a paradigm shift in translational stem cell research, and the role of biomaterials in stem cell-based regenerative medicine.
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Could fingerprints play a role in drug trials of the future? A forensic scientist’s perspective
Although readers of Drug Target Review may be more focused upstream of clinical trials in the drug discovery pipeline, the efficacy of clinical trials should also be of interest. Millions of pounds invested in drug discovery in the laboratory could easily go to waste if the clinical trials stage is…
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13th International Conference on Metabolomics and Systems Biology
Euro Metabolomics 2018 will be a platform to investigate on recent research and advancements that can be useful to the researchers.
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New study discovers cancer-relevant protein shield
Researchers have uncovered a new protein shield that aids in repairing damaged DNA in cells and affects resistance to drugs used for breast cancer treatment...
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Blood test may predict future risk of cardiovascular events
A study of 27,000 women finds that branched-chain amino acid levels in the bloodstream are as predictive of heart disease as LDL cholesterol, other risk factors...
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How the study of lipidomics is benefiting from recent advances in mass spectrometry
There are no short-cuts in the complex field of lipidomics, explains Cristina Legido-Quigley, a Principal Investigator in Systems Medicine at Steno Diabetes Center Copenhagen in Denmark and at King’s College London.
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Versatile applications of next-generation sequencing in pharmaceutics
Next-generation sequencing (NGS) technologies hold great promise for unravelling the mysteries of biological systems, with the advent of DNA sequencing methods having greatly accelerated biomedical research, gaining broad applicability in disease diagnosis and therapeutics in recent years...
