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New stem cell model to test treatments for neurodegenerative disorders
The team found that astrocytes inhibit growth of precursor cells that become myelin, and speed up the neural network in the brain...
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Analytical Techniques
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Is acidity the weakness of cancer cells?
Cancer cells proliferating in alkalinity should be more vulnerable in acidic environments, so decreasing the pH may result in decreased proliferation...
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Monoclonal antibodies produced by new cell lines hope to improve drugs
Many biopharmaceutical companies look to produce biosimilars soon, since the patents on the original mAb expire over the next few years...
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Susceptible genes for childhood nephrotic syndrome identified
A specific haplotype was identified as having the highest risk of development, with another showing the lowest risk...
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CMPK2 inhibitor could lesson symptoms of common illnesses
CMPK2 inhibitors may reduce inflammation, pain and tissue damage in arthritis and gout and in Alzheimer’s may slow loss of cognitive function...
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Blood test predicts the best treatment for prostrate cancer
The study showed that patients testing positive for AR-V7 responded better to taxane-based chemotherapy and negative to hormone-targeted therapy...
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Adapting drug discovery to Artificial Intelligence
Drug discovery has always been challenging; today, more so than ever. While there has been success in addressing many diseases, others remain intractable...
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Improving the translation of disease biology though phenomics
How times change. Up to 15 years ago, you would be hard-pressed to find a drug discovery conference with a track dedicated to phenotypic approaches. The underpinning science was called high-content imaging or analysis, being mainly confined to academic drug discovery labs and a handful of pioneers in industry. but…
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Urine tests are important in diagnosing myeloma
It may be better to examine the urine and the blood of patients suspected of tumours of the plasma cells...
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pGENMi predicts genomic features associated with drug responses
A new system, pGENMi, could predict genomic features associated with drug responses, by identifying differences in gene expression...
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Discovery of statistical method identifies cancer predisposition
New statistical method, ALFRED, could identify predisposition for cancers by using cancer genome data sets to identify risk variants.
whitepaper
Product hub: The Thermo Scientific™ CellInsight™ CX7 LZR High Content Analysis System
Introducing the Thermo Scientific™ CellInsight™ CX7 LZR High Content Analysis System: the only imaging and analysis platform for advanced performance in screening and analysis.
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Expert view: High-throughput binding kinetic analysis – is it the new frontier in drug discovery?
Sometimes the difference between identifying a partial or super agonist is only the time point at which the binding reaction is measured.
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Stem Cells In-Depth Focus 2018
In this issue: urine-derived stem cells offer an innovative platform for drug testing and disease modelling, a paradigm shift in translational stem cell research, and the role of biomaterials in stem cell-based regenerative medicine.
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Could fingerprints play a role in drug trials of the future? A forensic scientist’s perspective
Although readers of Drug Target Review may be more focused upstream of clinical trials in the drug discovery pipeline, the efficacy of clinical trials should also be of interest. Millions of pounds invested in drug discovery in the laboratory could easily go to waste if the clinical trials stage is…
