whitepaper
Tech note: Benefits of water immersion lenses for HCS
Water immersion lenses provide: brighter images from HCS samples; faster and gentler imaging; higher quality images from both 2D and 3D samples.
List view / Grid view
Cell-based assays
news
Heart-muscle patches improve heart attack recovery
Large, human cardiac-muscle patches created in the lab have been tested, for the first time, on large animals the patches significantly improved recovery from heart attack injury...
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Application note: Functional GPCR studies using AlphaScreen cAMP Detection Kit
In this application note, PerkinElmer demonstrates the ease and utility of the AlphaScreen® cAMP assay for detecting both agonist and antagonist-induced cAMP responses within cells.
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Application note: LANCE Ultra TR-FRET – based detection and modulation of Phosphorylated STAT3 levels in human cells
In this application note, PerkinElmer demonstrates how LANCE® Ultra, a homogeneous assay format, can be used to quickly and accurately assess modulation of pSTAT3.
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Scientific poster: Developing protein: Protein Interaction (PPI) assays with AlphaLISA and LANCE TR-FRET
In this scientific poster, PerkinElmer demonstrates the ease and utility of using AlphaLISA® and LANCE® TR-FRET homogenous assay forms for studying PPIs.
article
Expert view: Optimising the hit-to-lead workflow
Hits identified in high-throughput screens are evaluated within the hit-to-lead phase of drug discovery, where they undergo an iterative optimisation process employing a variety of techniques to identify promising lead compounds to move forward to the lead optimisation phase.
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Q&A: Implementing ADCC assays in QC: when donor variability isn’t an option
DiscoverX recently introduced the single donor-derived KILR CD16 Effector Cells to ensure assay reproducibility for screening, characterisation, and QC lot release of antibody drugs.
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Expert view: Addressing the big challenges in drug screening
One of the biggest challenges facing drug discovery across all therapeutic modalities (small molecule, biologics, and cellular) remains the balance between physiological relevance and throughput.
news
Charles River Laboratories presents newly expanded capabilities at Neuroscience 2017
Charles River Laboratories International, Inc. announced that its team of neuroscience drug discovery experts is presenting 27 scientific posters, both independently and collaboratively with clients, at Neuroscience 2017, the 47th annual meeting of the Society for Neuroscience (SfN).
webinar
Implementing ADCC assays in QC: When donor variability isn’t an option
6 October 2017 | By DiscoverX Corporation
In this webinar, we discussed how two qualification studies on KILR CD16 Effector Cells demonstrated accuracy and precision in different assays formats.
whitepaper
Application note: A high-throughput, radioactivity-free assay for cell-mediated cytotoxicity
In this application note, IntelliCyt Corporation demonstrate a fast, efficient, radioactivity-free CMC assay with low sample input requirements, enabling miniaturisation to 384-well plates, using the iQue® Screener...
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Application note: Application of MultiCyt QBeads for high throughput cytokine profiling in human peripheral blood mononuclear cells
In this application note IntelliCyt Corporation report on the development and validation of their family of MultiCyt QBeads for the detection of cytokines in a high-throughput screening application on the iQue Screener...
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Expert view: Innovations in 3D
Physiologically relevant models to evaluate the effects of drug candidates early in the drug discovery and development process are becoming increasingly important to develop. Various 3D cell/tissue models have emerged offering relevant environment for ex vivo assays, but significant progress is required to streamline and automate the end-to-end workflow. Several…
whitepaper
Application note: Characterising chemokine receptor inhibitors with Alpha SureFire Ultra assays
In this application note, PerkinElmer discuss how their ValiScreen CXCR2 GPCR cell line (#ES-145-C) was utilised to examine the downstream effects of chemokine receptor modulation using multiple blocking antibodies and a small molecule...
news
New headquarters in Scotland strengthens drug discovery research
A provider of products and services for research in stem cells, drug discovery, human tissues and 3D cell culture has opened its European headquarters in Glasgow, UK...
