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Usher syndrome: first nonhuman primate model
US researchers evaluate an experimental gene therapy in the first ever nonhuman primate model for Usher Syndrome.
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CRISPR
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Researchers develop novel method to insert large DNA sequences more accurately in cells
The scientists say that the engineered CRISPR enzymes could overcome key limitations for eventual use to treat genetic diseases irrespective of a patient’s particular mutation.
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New system for safer CRISPR-based gene drive testing and development
US researchers outline the development of a new system for testing and developing CRISPR-based gene drives in the laboratory, and safely converting them into tools for potential real-world applications.
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Novel cancer vaccine simultaneously kills and prevents brain cancer
US researchers develop a dual-action cell therapy engineered to eliminate established tumours and train the immune system to eradicate primary tumour and prevent cancer’s recurrence.
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Researchers generate organoid model for gastroesophageal junction cancer
The scientists discovered that dual knockout of genes in organoids grown from human tissue can generate a model of a potential therapeutic target for gastroesophageal junction cancer.
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On the CRISPR horizon: democratising access to genome-editing technologies
Dr Douglas Ross-Thriepland and Dr David Walter, from the Functional Genomics Centre (FGC) – a joint venture between Cancer Research UK’s (CRUK) drug discovery engine, Cancer Research Horizons, and AstraZeneca – speak to Drug Target Review about their work. The centre’s focus is on genetic screening; cancer models; CRISPR reagent…
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Drug Target Review’s top content picks from 2022
In this article, Drug Target Review’s Izzy Wood and Ria Kakkad share some of the most ground-breaking moments from drug discovery this year.
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Keeping T cells strong and improving cancer immunotherapy
The tumour microenvironment can prevent some T cells from carrying out their immunotherapeutic duties. In this Q&A, Dr Brian Shy, Clinical Instructor at the University of California, San Francisco (UCSF) Department of Laboratory Medicine, describes a recent study wherein he and fellow scientists discovered a strategy to strengthen T cells…
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New MACHETE technique developed to slice into cancer genome
Sloan Kettering Institute (SKI) researchers have developed a new machete technique to slice into the cancer genome and study copy number alterations.
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Five recent CRISPR drug target discoveries
This article highlights five of the latest findings revealed using CRISPR that could be used in the development or design of new therapies.
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First use of CRISPR to substitute genes for cancer treatment
US scientists, using CRISPR technology, removed specific genes in humans to allow the immune system to be more activated against cancer.
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Researchers make progress towards CRISPR-based microbiome editing
US researchers have engineered bacteriophages to deliver CRISPR-Cas payloads for targeted editing of a bacterium.
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Researchers find that reduction in protein synthesis could lead to Feingold syndrome
The researchers used a zebrafish model to test mutations in Mycn, a gene which causes Feingold syndrome.
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Developing novel genome editing tools
In this Q&A, Dr Stephen Jones from Vilnius University Life Sciences Center discusses his work on the recent developments in genome editing tools at the university.
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New gene target for small-cell lung cancer discovered
Deleting the gene POU2AF2 kills cancer cells in deadly subtype of small-cell lung cancer.
