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Synapse protecting protein could be a target for Alzheimer’s therapies
Researchers suggest the SRPX2 protein, which inhibits complement system-dependent synapse removal could be a target for novel Alzheimer’s and schizophrenia therapies.
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Disease Research
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Toxoplasma gondii hijacks host stress mechanisms to spread through the body
A new study reveals that the Toxoplasma gondii parasite acts through the IRE1 protein to cause infected cells to migrate through the body, spreading the parasite.
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Vitronectin could be a promising drug target for macular degeneration
Scientists demonstrate that vitronectin is responsible of the formation of deposits in dry age-related macular degeneration and suggest inhibitors could slow disease progression.
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Revealing the genetic signature of neurodegenerative disease
Which immune cells contribute towards immune-induced neurodegeneration and how could this knowledge enable conditions such Alzheimer’s and multiple sclerosis to be treated?
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Huntingtin protein disrupts axonal transport system within neurons
Researchers show that the mutated huntingtin protein associated with Huntington’s disrupts the transport of essential proteins within the neuron, potentially highlighting an early cause of the disease.
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Could the Nsp1 protein be a novel drug target for COVID-19?
A study of the SARS-CoV-2 nonstructural protein 1 (Nsp1) showed it can supress translation and inhibit anti-viral defence mechanisms, making it a potential target for drugs.
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CBD may combat cytokine storms and respiratory distress caused by COVID-19
Scientists found in a murine model of acute respiratory distress syndrome (ARDS) that cannabidiol (CBD) helped the lungs recover from excessive inflammation caused by COVID-19.
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Providing cancer immunotherapies with a boost could reduce cancer recurrence
Researchers reveal drugs inhibiting Neuropilin-1 (NRP1), a protein expressed on T cells, could improve the efficacy of immunotherapies.
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Studying neural circuitry provides new drug targets for autism spectrum disorders
The researchers suggest the regions they identified in their study could be targeted to improve dysfunctional behaviours associated with autism spectrum disorders, even in adults.
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Interferon deficiency and heightened inflammation are hallmarks of severe COVID-19, say researchers
The newly identified hallmarks of critical COVID-19 indicate a combination of interferon supplementation and anti-inflammatory therapies could be effective in treating patients with severe COVID-19 symptoms.
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New ARRIVE 2.0 guidelines published to improve animal research
The ARRIVE 2.0 guidelines outline what researchers should include in reports to increase reproducibility and reliability for peer-review, and reduce certain ethical concerns surrounding the use of animals in research.
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Protein promotes the respiratory complications of Cystic Fibrosis
Researchers reveal the Vav3 protein is responsible for the formation of bacterial docking stations in the airway cells which promote the recurrent lung infections seen in Cystic Fibrosis patients.
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Key regulator of sperm maturation revealed as a target for male infertility treatments
Scientists demonstrated that NELL2, a factor release by the testis, is essential for sperm to mature into motile cells able to fertilise an egg.
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Pre-clinical study supports remdesivir as COVID-19 treatment
Scientists demonstrated that remdesivir can inhibit SARS-CoV-2 replication in human lung cells and improve lung function in mice with COVID-19.
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Proteomic map of human lung adenocarcinoma revealed
The proteomic map based on data from 103 patients reveals novel prognostic biomarkers and potential drug targets for lung adenocarcinoma.
