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Elimination of c-Raf kinase induces regression of advanced lung tumours
A study has shown how the elimination of the c-Raf kinase by genetic manipulation causes the regression of Kras oncogene-driven advanced lung tumours...
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Drug Development
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G-CSF protein involved in cocaine addiction
Researchers have identified a protein produced by the immune system that could be responsible for the development of cocaine addiction...
news
Blood-vessel-on-a-chip provides insight into new anti-inflammatory drug candidate
Researchers have discovered that synthetic APC-mimicking molecules provide anti-inflammatory and anti-thrombotic protection to endothelial cells without interfering with blood clotting...
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Hear from Janssen and Antikor Biopharma at SMi’s ADC Conference, April 2018
SMi's ADC conference will be bringing a global presence from Pfizer, Genentech, Ablynx, Spirogen, Seattle Genetics, Medimmune, Antikor Biopharma, Heidelberg Pharma and more...
news
Promising preclinical drug candidate suppresses HIV
A team of researchers have tested a chemical compound that suppresses HIV, protects immune cells, and remains effective for weeks with a single dose...
news
Anti-obesity drug shrinks fat without suppressing appetite
Researchers have discovered a drug that has been shown to selectively shrink excess fat by increasing fat cell metabolism...
article
Rational drug design: How far have we come?
From the early use of Hansch parameters and Topliss Trees to today’s computational structure–activity techniques, medicinal chemists have long sought to rationalise drug design to find the quickest and most resource-efficient route to market. But while modern strategies are more reliant on statistical algorithms and vast data libraries, these founding…
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Nano-medicine inhibits progression of pancreatic cancer
Survival rates in pancreatic cancer linked to the inverse correlation between specific oncogene and tumour suppressant microRNA...
article
Machine learning approaches as tools to accelerate drug discovery
Computational methods based on machine learning approaches are being introduced increasingly widely to screen the large number of molecules that have never participated in the drug discovery process, but which might have significant drug development potential. This article considers the latest advances in machine learning as applied to drug discovery...
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IONIS-HTTRx lowers deadly Huntington’s disease protein
The first drug targeting the cause of Huntington’s disease was safe and well-tolerated in its first human trial…
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Scientists discover a small molecule that halts kidney disease progression
A team of researchers set out to discover the disease pathways of a rare genetic kidney disease and found a compound that stops the disease in its tracks.
news
Charles River announces success of integrated discovery project with ENYO Pharma
Capture compound mass spectrometry technology enables target identification...
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CXCL5 protein found to stimulate tumour growth in prostate cancer
Researchers identify a pathway that causes tumour acceleration in metastatic prostate cancer cells...
whitepaper
Whitepaper: In search of a disease-modifying agent for Parkinson’s disease: a discovery story
Are selective, brain-penetrant inhibitors of LRRK2 an answer?
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Scientists create “tracking” nanoagents to illuminate very small diseased tissues
Polymer nanoagents that can ‘light up’ tiny areas of diseased tissues that conventional methods fail to detect, have been created by a research team led by NTU Singapore.
