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Study suggests beta cell regeneration driven by circadian rhythms
Researchers have shown that the internal clock controls the regenerative mechanism behind beta cells in diabetic mice.
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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RNA structures of SARS-CoV-2 reveal potential drug targets
The SARS-CoV-2 RNA genome structure has been studied by researchers who identified several potential drug targets.
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Novel antibody-drug candidate to treat pancreatic cancer developed
Scientists have developed a new antibody-drug conjugate (ADC), made from ICAM1, an antibody that targets pancreatic cancer and the cytotoxic drug DM1 (mertansine).
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T cells facilitate chronic lung injury in the elderly after viral infections, finds study
After viral pneumonia in elderly mice, there is an accumulation of dysfunctional tissue-resident memory T cells in the lungs which scientists suggest may drive chronic inflammation and fibrosis.
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Pre-existing coronavirus antibodies could protect against new COVID-19 strains
Researchers have found antibodies, from infection with common cold coronaviruses, can also target SARS-CoV-2 - especially in children.
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Researchers discover how SARS-CoV-2 infects and replicates in host cells
A team has revealed how SARS-CoV-2 infects cells, suggesting that targeting its RNA with drugs would stop the virus replicating.
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Inflammatory bowel disease drugs could combat COVID-19, study suggests
Anti-inflammatory therapies for inflammatory bowel disease could aid recovery from COVID-19 as they target an enzyme involved in both diseases.
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Developing drugs for disordered proteins
Scientists have developed a drug-like molecule to target amyloid-beta, a disordered protein implicated in Alzheimer's disease that has been considered undruggable.
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Team identifies new potential approach to treat multiple sclerosis
Researchers have prevented immune cells from attacking myelin in mice, which stopped the progression of multiple sclerosis (MS).
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Protease inhibitor aprotinin shows promise against SARS-CoV-2 in cells
Researchers have found that aprotinin, an approved drug for influenza in Russia, combats SARS-CoV-2 in cells.
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Novel therapeutic approach shows promise in mice with COPD
By blocking the lymphotoxin beta receptor signalling pathway, researchers were able to prevent COPD progression and induce a full restoration of lung tissue.
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Researchers use somatostatin to treat Alzheimer’s in mice
A team fused the peptide somatostatin to a brain transport protein and found it treated memory loss associated with Alzheimer's in mice.
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Autoantibodies and over-active neutrophils may be cause of COVID-19 blood clots
According to a new study, blood clots in patients with severe COVID-19 are caused by an autoimmune antibody that circulates in the blood and attacks cells.
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Researchers reveal how allergens may trigger itching
Certain sensory neurons and Substance P are potential drug targets for the development of novel allergy preventions or treatments, according to scientists.
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Researchers discover novel cancer immunosuppression mechanism
According to the study, the transcription factor IRF4 drives T cell differentiation and immunosuppression in multiple human cancers.
