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New way to target treatment-resistant cancers identified
A new mechanism by which cancer cells become resistant to chemotherapy has been found which could lead to a new target for drugs.
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
news
LVNC congenital heart condition linked to faulty signalling pathway
A new study, which has shown that the congenital heart condition LVNC could be be caused by signalling defects, may lead to potential therapies.
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Making tumour cells stiff could prevent cancer metastasis
A study has demonstrated that the stiffness of cells indicates whether a tumour will spread and inducing this state could help to avoid metastasis.
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Ten genes revealed to contribute to development of schizophrenia
Whole exome sequencing has been used by researchers to reveal 10 genes implicated in the development of schizophrenia.
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Study finds astrocytes critical in progression of Huntington’s disease
The new research shows that astrocytes contribute to Huntington’s disease symptoms, but suppressing a mutation stops the disease from progressing.
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Selective inhibitor could reduce resistance to cancer therapies
A study has found a selective inhibitor for an enzyme that allows cancer cells to mutate and become resistant to treatments.
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Platform may find new options for mental health treatment
A drug discovery platform for mental health treatment could also help to identify mechanisms for the treatment of substance use disorders.
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Mucus has been shown to tame microbes in new study
Glycans, which are found in mucus, have the ability to regulate how microbes behave and could lead to new therapeutics.
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Dementia spreads via connected brain networks, finds study
New findings on dementia reveal that brain atrophy spreads via connected brain networks, rather than simply adjacent areas of the brain.
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Researchers develop new immuno-oncology technique
A team has used viral gene editing and CRISPR to form a system that marks tumours for destruction, potentially improving immunotherapies.
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Cancer-suppressing cells identified in pancreatic cancer
Cells containing Meflin play a role in restraining the progression of pancreatic cancer and could lead to new therapies against the disease.
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Microglia critical for neurodegeneration in mice, study finds
Microglia brain immune cells are vital in conjunction with the APOE4 gene during the development of Alzheimer’s in mouse models, researchers have found.
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‘Tricking’ bacteria could lead to more effective antibiotics
A technique to 'trick' bacteria into revealing pores in their cell walls has been developed and targeting these could make antibiotics more effective.
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Bacterial strain identified that determines fate for rotavirus sufferers
Scientists in the US have identified a particular bacterial strain, Segmented filamentous bacteria (SFB), that can prevent and cure rotavirus in mice.
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Best targets for immunotherapy identified by new model
A new algorithm has been developed which personalises which cancer mutations are best targets for immunotherapy.
