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Epidemiological data on SARS-CoV-2 uncovers insights into mutations
Researchers have analysed 750 samples from patients with SARS-CoV-2 to discover details about its transmission and mutational properties.
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Epigenetics
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Novel technique reveals Parkinson’s changes how neurons sense oxygen
The new approach enables researchers to isolate brain cells associated with Parkinson's disease and study their gene expression patterns.
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Cellular senescence as a drug target
New research reveals that age-related declines in cellular function and proliferation occur in multiple stages, accompanied by different inflammatory responses.
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Epigenetic marks could be the target of future Alzheimer’s therapies
New findings suggest that late-onset Alzheimer's Disease (AD) is driven by epigenetic changes in the brain.
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Selectively increased Dnmt3a2 protein expression improves memory recall
Researchers found increasing levels of Dnmt3a2 in neurons activated at the time of making a memory, improved its recall in mice.
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Novel microfluidic and sequencing method enables epigenetic studies
A new microfluidic technology has been developed which can profile histone modifications with as few as 100 cells per assay.
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Results from first epigenetic study in 3D human cancer cells published
A new paper describes the first full study of the epigenetics of human tumour organoids, suggesting this could be used to develop novel oncology treatments.
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Novel cell reprogramming cocktail could advance regenerative medicine
Scientists have showed that a three inhibitors (3i) cocktail could reprogramme fibroblasts to a naïve embryonic stem cell-like state and remove disease-associated epigenetic changes.
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Possible novel cognitive anti-ageing targets identified
Researchers have shown that two epigenetic regulators could be targeted to improve cognitive and behavioural decline in age-related diseases like Alzheimer’s.
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HDAC3 inhibitors: a potential treatment for non-Hodgkin lymphomas?
A murine study found histone deacetylase 3 (HDAC3) inhibitors reverse epigenetic changes caused by CREBBP mutations found in lymphomas and could be developed into a novel therapy.
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Epigenome editing used to reverse gene mutation in mice
A study has demonstrated the success of changing the genome of mice, regulating the production of the C11orf46 gene.
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Root of childhood kidney cancer discovered
The earliest genetic root of Wilms' tumour has been discovered, which could not only lead to improved treatments but to one day being able to screen for cancers like this before tumours develop.
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Leukaemia cells can transform into non-cancerous cells
A new discovery that leukaemia type B cells can transform into different cells through epigenetic changes could lead to more effective therapies.
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Machine-learning algorithm developed to aid in epigenetic drug discovery
A machine-learning algorithm has been created that automates high-throughput screens of epigenetic medicines.
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Expert view: Challenges in drug discovery screening
The basic premise of drug discovery screening necessitates that the biological assays upon which it depends can be performed in a reproducible manner. In addition, the techniques employed must generate results that are biologically relevant and actionable.
