Hit-to-Lead

Application note: qPCR to Measure Minute Volumes in High Throughput

19 November 2019 | By Analytik Jena

Improve the reproducibility of the real-time results in 384 well format with the application of a qPCR using a pipetting robot & standardized sample setup.

Novel metabolic-focused high-throughput screening method developed

19 November 2019 | By Victoria Rees (Drug Target Review)

Researchers have created a new high-throughput screening system which could identify new drugs by focusing on nucleotide metabolism.

Application note: Using SYPRO^® Orange to Detect Protein Melting Temps

18 November 2019 | By Analytik Jena

Investigation of thermal protein stability in high throughput using the application of thermal shift assay using SYPRO ® Orange in 96 well format.

Application note: Detection of Mastitis Pathogens in Raw Milk

18 November 2019 | By Analytik Jena

Detection of four pathogens of mastitis diseases using qTOWER³ in combination with extraction and detection systems for DNA diagnostics.

Application note: Automated DNA Extraction and Species Analysis

18 November 2019 | By Analytik Jena

Combining automated nucleic acid extraction, photometry and qPCR for easy-to-use and highly sensitive species analysis of cheese.

Application note: Automated Extraction of High Molecular Weight DNA

14 November 2019 | By Analytik Jena

SmartExtraction significantly simplifies the entire automated workflow of DNA extraction.

Application note: Multiplex Fluorescent Western Blot Detection

13 November 2019 | By Analytik Jena

Challenge: One touch imaging of multiple proteins on the same blot with NIR fluorescent tags. Solution? Automated imaging with the UVP ChemStudio.

eBook: Simple as a Selfie: One-Button Scientific Imaging

13 November 2019 | By Analytik Jena

Proper signal visualization, detection, and quantification are paramount to the acquisition of accurate and reproducible data...

Application note: In Vivo Imaging with GFP

12 November 2019 | By Analytik Jena

Challenge: Non-invasive imaging of a patient-derived orthotropic mouse model of pancreatic cancer expressing GFP. The solution? In vivo imaging.

eBook – Getting the Inside Story: In Vivo Imaging

12 November 2019 | By Analytik Jena

In vivo imaging has been an indispensable and powerful tool in biomedical research, enabling a number of significant breakthrough discoveries.

Analytik Jena

New horizons in small molecule solubility screening

22 October 2019 | By Halo Labs

Aqueous solubility of small molecule compounds is an essential parameter during the hit-to-lead stage of drug discovery as well as lead optimization and formulation. Low solubility can result in misleading ADMET/DMPK analyses if some fraction of a compound precipitates. Watch on-demand to find out more!

New compound keeps cells alive and functioning in a healthy state

7 October 2019 | By Rachael Harper (Drug Target Review)

A world-first compound that can keep cells alive and functioning in a healthy state could be revolutionary for medical emergencies.

The challenges of hit-to-lead in drug discovery

7 October 2019 | By Victoria Rees (Drug Target Review)

A study that identified 12 novel compounds that may prove valuable against new drug targets for leishmaniasis and Chagas disease was not without complication. Here, we discuss the findings but also the challenges the researchers reported in their hit-to-lead study.

High-throughput screening used to discover new class of antibiotics

27 September 2019 | By Victoria Rees (Drug Target Review)

Researchers have used a high-throughput screening method to test over 125,000 molecules and identify a new class of antibiotics.