New method for developing medical imaging tracers discovered
21 June 2019 | By Drug Target Review
A new medical imaging tracing method has been discovered by scientists which can better track drugs in the body.
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Imaging
Norovirus structure imaged, providing potential for vaccine development
17 June 2019 | By Victoria Rees (Drug Target Review)
Researchers have been able to image noroviruses, providing significant information for the development of therapeutics.
High-content imaging: challenges of the 3D world
17 June 2019 | By Jeremy C. Simpson, Margaritha M. Mysior
The potential of three-dimensional cell culture models is now well-recognised by scientists; however, there are still some challenges. Margaritha Mysior and Jeremy Simpson address some of the common challenges of working with spheroids and organoid models – including how they are developed and how to obtain high-resolution, high-content images and…
Image-based characterisation of cancer biotherapeutics
17 June 2019 | By Laura Murch, Siobhán Leonard, Victoria Juskaite
Scientists from LifeArc, an independent medical research charity in the UK, explain how they’re using the latest imaging technologies to progress drug discovery campaigns and identify the most promising candidates for antibody-based therapies.
Expert view: High-content screening of complex physiologically-relevant cell models
10 June 2019 | By Andy Bashford PhD (European Imaging Application Scientist at Molecular Devices)
High-content screening (HCS) approaches have become increasingly common in drug discovery with HCS technologies integrated across the drug discovery pipeline. Here we discuss recent developments in this arena.
Imaging In-Depth Focus 2019
6 June 2019 | By Drug Target Review
In this in-depth focus, the challenges of imaging are explored including how to develop high-resolution images. Also discussed are new imaging technologies to aid drug discovery.
Phenotypic profiling in drug discovery
5 June 2019 | By Ina Rothenaigner, Kamyar Hadian, Sean Lin
Image-based phenotypic profiling of small molecules has been used for identification and characterisation of small molecules in drug discovery and can provide important insights into their mechanisms of action (MOA). This article discusses the use of phenotypic profiling in drug discovery and how machine-learning algorithms could help improve objectivity, processing…
Drug Target Review Issue 2 2019
5 June 2019 | By Drug Target Review
In this issue: novel approaches to produce radiolabelled antibodies, the use of CRISPR/Cas9 to accelerate the development of targeted therapies and utilisation of stem cells to study the effects of cannabis on neuronal development.
High-res 3D structure of proteins inside living eukaryotic cells determined
3 June 2019 | By Drug Target Review
Nuclear magnetic resonance measurement and state-of-the-art computational science reveal protein structures in higher eukaryotic cells.
New method could speed up drug development and diminish drug trial fails
21 May 2019 | By Drug Target Review
A new method of assessing the actions of medicines by matching them to their unique protein receptors could accelerate drug development.
In-depth research maps virulence factor of the influenza A virus in real time
21 May 2019 | By Drug Target Review
Findings from a recent study could lead to the development of therapeutic approaches against influenza A viruses.
Innovative mechanobiology research expands understanding of cells
13 May 2019 | By Drug Target Review
Researchers have developed a new technology that allows them to probe cell changes without disturbing the cell’s physiology.
Method for radiolabelling antibodies against breast cancer developed
25 April 2019 | By Drug Target Review
Researchers from the University of Zurich have created a new method for radiolabelling antibodies using UV light - with proteins being ready-to-use for cancer imaging or therapy in less than 15 minutes.
Optical imaging technique to detect tiny tumours
8 March 2019 | By Iqra Farooq (Drug Target Review)
A method of imaging using longer wavelengths could mean that tiny tumours and clusters of cancer cells may be detected earlier than current methods allow...
MRI sensor to image activity deep inside the brain
22 February 2019 | By Drug Target Review
A method of imaging calcium activity that is based on magnetic resonance imaging (MRI) could help to image deep within the brain...
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