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Immunotherapy could cure advanced pancreatic cancer
Immunotherapy using 'educated' killer cells could be a potential cure for pancreatic cancer, with researchers eliminating all signs of cancer from mice...
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Efficacy of PET imaging in managing chronic liver diseases
PET imaging could be used as a non-invasive substitute to painful and complicated liver biopsies for chronic liver disease...
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Expert view: Unravelling the complexities of GABAA subunit selectivity in drug discovery
GABAA receptors represent a large and complicated family of ion channels that consist of at least 16 subunits (α1-6, β1-3, γ1-3, δ, ε, π, θ) that have been shown to be vital for the normal functioning of the brain. These inhibitory ligand-gated channels have been shown to beimportant in sedation,…
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Application Note: Evaluating the specificity and potency of PD-1 and PD-L1 blocking antibodies using AlphaLISA human and mouse PD-1/PD-L1 binding kits
Cancer immunotherapy utilises components of the immune system to treat cancer patients. These therapies are designed to work with a patient’s immune system to increase native anti-tumour responses. One type of immunotherapy relies on antibodies to bind to and inhibit the function of proteins expressed by the cancer cell...
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Injecting VIP into the eye improves corneal transplant survival
Results using mouse models suggest that vasoactive intestinal peptide may provide a new method of improving the outcomes of corneal transplant surgery...
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Novel vaccine approach proves powerful against Zika virus
VSV acted as a vehicle to deliver the genes of some proteins from the Zika virus into mouse models, leading to immunity build up in the mice...
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New drug for ALS ready for clinical trials
Previous studies have suggested that a gene therapy drug may be used to treat ALS...
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Promising drug targets for t-cell lymphoblastic leukaemia
Silencing the gene behind the production of HSP90, a target in the HSF1 pathway, effectively kills leukaemia cells, without affecting healthy cells...
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Exploring horizons in 3D microscopy: what the future holds
The microscope slide is flat (2D), but the world around us is not – despite the flat-earth theories. We need volume information about our samples, ideally with high resolution in all three dimensions as well as over time – the fourth dimension...
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Key role of PI3Ky in Chagas disease described
The expression of PI3Ky increases during infection by T.cruzi, providing an essential response controlling the parasite and avoiding inflammation...
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Genomics in drug development and safety testing; from target identification to genomic toxicology
In the annual report of the Chief Medical Officer, 1 Dame Sally Davies has declared that we are part of ‘generation genome’ – the era in which we reap the rewards of our advances in genomic technologies and improvements in our understanding of the whole genome in human health.
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Streamlining drug discovery assays for cancer and cardiovascular disease
For lead optimisation, target-based assays are still the most affordable means of rapidly performing fast iterations and remain core to screening. However, the desire for biological relevance is driving ongoing growth in cell-based assays.
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Expert view: How high-content platforms keep pace with the changing face of cell-based drug screening
For the next generation of cell biologists, 3D cell culture and analysis has opened doors to taking applied research one step further.
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Expert view: Improving R&D productivity with novel screening approaches
The pursuit of improved R&D productivity rates coupled with decreased cycle times has dominated pharmaceutical discourse in recent years.
