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New treatment target discovered for sleep apnoea
A recent study in mice revealed that an ion channel already proven to affect blood pressure in obese mice plays a role in suppressing their breathing, influencing sleep apnoea.
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Ion Channels
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Antibody pipelines – the pharma perspective
Dr Erik Vernet, Director of Antibody Technology at Novo Nordisk, discusses antibody discovery and development workflows, including the role of informatics processes, in this Q&A.
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Under the microscope: Leveraging CRISPR libraries for target discovery
CRISPR libraries can be highly useful for target identification, gene screens and drug discovery. Dr Erik Willems, Senior Manager of Cell Biology at Thermo Fisher Scientific, discusses the company’s CRISPR libraries and the advantages they can offer scientists.
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“Untreatable” cases of cystic fibrosis may be undermined by new therapy
An experimental drug suggests that therapy for currently untreatable cases of cystic fibrosis is “clearly achievable”.
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Molecules from resin combat epileptic seizures in pre-clinical studies
Drug molecules from pine and spruce trees can affect certain ion channels and had antiseizure effects in pre-clinical studies.
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Gramicidin A antibiotic analogues safe for human cells developed
A team has developed 10 new versions of the antibiotic gramicidin A, which they say should be safe for use in pills or injections.
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Study reveals potential targets for upper motor neuron disease therapies
The researchers revealed the mechanism by which signalling becomes dysfunctional in upper motor neuron (UMN) diseases, such as amyotrophic lateral sclerosis (ALS).
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Ion channel ball-and-chain mechanism imaged after decades of attempts
Scientists have imaged the ball-and-chain mechanism using cryogenic electron microscopy and hope their work could be applied in the design of novel therapeutics.
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Mechanism behind Piezo proteins discovered using imaging technique
A new study has used a combination of imaging methods to understand how the Piezo protein works, improving research into treatments for conditions such as high blood pressure.
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Researchers identify potential enterovirus drug target
A study has discovered a pathway that allows the enterovirus to successfully infect cells and promote genome release which could be a therapeutic target.
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Expert view: Unravelling the complexities of GABAA subunit selectivity in drug discovery
GABAA receptors represent a large and complicated family of ion channels that consist of at least 16 subunits (α1-6, β1-3, γ1-3, δ, ε, π, θ) that have been shown to be vital for the normal functioning of the brain. These inhibitory ligand-gated channels have been shown to beimportant in sedation,…
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Expert view: Managing the complexity of finding new targets and drugging the undruggable
Assessing targets that are unable – or rather, extremely difficult – to reach pharmacologically, has prevented researchers from achieving desired clinical successes, most notably in the realm of cancer research. However, many advances are being made to shedlight on these difficult yet desirable target areas.
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13th International Conference on Metabolomics and Systems Biology
Euro Metabolomics 2018 will be a platform to investigate on recent research and advancements that can be useful to the researchers.
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Nicotinic receptor research paves way for targeted dementia therapy
A new study which identifies how acetylcholine impacts learning and memory by acting at different receptors could prove significant in the drive to develop more targeted and effective therapies for dementia...