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Targeting TNF to treat Dupuytren’s disease, frozen shoulder and POCD
Dr James Woody discusses off-patent indications for anti-TNF to address unmet patient needs in pain, inflammation and beyond.
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Molecular Targets
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Brain organoids reveal mechanisms of virus-induced microcephaly
Researchers have shown how different viruses such as HSV-1 and Zika can lead to microcephaly using brain organoids.
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Exploring the connection between COVID-19 and diabetes
Dr Brittany Busse discusses why COVID-19 can influence the onset of diabetes and how this could shape the development of therapeutics.
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Reduced levels of H2S in rat brains protects against dementia
A study has shown that treatments to reduce levels of hydrogen sulphide (H2S) in the brain may help to prevent dementia.
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Self-assembling nanofibres could prevent damage from inflammation
A team has demonstrated in mouse models that a self-assembling nanofibre material could limit the damage caused by cytokines in inflammatory diseases.
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Team identifies potential drug to repurpose against melanoma
Researchers say that inhibiting NLRP3 with Dapansutrile could be an effective strategy to prevent melanoma tumour growth.
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Researchers discover strategy to reverse poor stress response in mice
Studying the mouse gene Ophn1, researchers have found its removal causes stressed behaviours, also identifying three ways to reverse this effect.
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Dynamic model of SARS-CoV-2 S protein reveals vaccine targets
A model of the SARS-CoV-2 Spike protein surface has uncovered vulnerabilities that researchers say could inform the development of COVID-19 vaccines.
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Team reveals miR-29 as regulator of processes for normal brain maturation
Researchers have shown that miR-29 can control brain maturation in mammals, presenting a target for autism, epilepsy and other conditions.
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X-ray screening reveals two promising SARS-CoV-2 drug candidates
Using a high-brilliance X-ray lightsource and protein crystallography, researchers have identified two drugs that inhibit the main protease of SARS-CoV-2.
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Alliance to create atlas of human genetic variants launched
The Atlas of Variant Effects Alliance will develop a map of human genetic variants to advance the understanding and treatment of disease.
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Revealed structure of enzyme could progress cancer research
Researchers have elucidated the 3D structure of the Taspase 1 enzyme, known to be involved in a range of cancers.
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Inhibiting Asc-1 protein function could present new drug target for obesity
Researchers have shown that loss of Asc-1 function could help obese patients maintain a healthy metabolism.
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Gold nanoparticles designed to seek out and isolate human bone stem cells
A team has designed gold nanoparticles to reveal specific bone stem cells, which could lead to treatments for major bone fractures.
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Novel opioid could provide pain relief alternative to fentanyl
NFEPP, a new opioid, inhibited colon pain in mice with colitis but did not cause the side effects associated with use of fentanyl.
