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Researchers reveal how key enzyme APT2 works in cells
Using X-ray crystallography and simulations, researchers have shown that APT2 is a hybrid between a lipid carrier protein and a hydrolase.
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Molecular Targets
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RNA protein shown to protect telomeres and support cancer proliferation
A team has revealed a function of ADAR1, responsible for RNA editing, discovering an isoform used for cancer growth, making it a drug target.
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Researchers reveal 3D structure responsible for gene expression
Researchers have produced the first 3D image of the Mediator-bound pre-initiation complex, key in the regulation of gene expression.
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New tool designed to add or remove sugar from proteins shows success
Researchers have developed a new tool that can add or remove sugar from proteins, which could be used to treat currently "undruggable" targets.
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Novel spectroscopic microscope images biological molecular conformations
A spectroscopic microscope has been developed by researchers to gather data on biological conformations faster and more accurately.
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Open source all-atom model of entire COVID-19 S protein released
Researchers have developed a video and model-building programme for other scientists to build full-length COVID-19 S protein models.
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If Columbus had a map… guiding the discovery of new drugs
Exploring large databases and selecting compounds of interest can be extremely time-consuming for researchers. Here, Sacha Javor, Horst Flotow and Jingwen Shi discuss a novel chemoinformatics approach for drug discovery.
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Antibody for amyloid beta oligomers could revolutionise Alzheimer’s field
Scientists have designed a high affinity antibody for pathogenic amyloid beta oligomers, a key driver of Alzheimer’s disease, for use in further research and as a potential diagnostic tool.
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Dynamics of GPCRs revealed using combination of approaches
A team used both structural and spectroscopic techniques to study the dynamics of cell surface G-protein coupled receptors (GPCRs).
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Collaboration to identify novel COVID-19 drug targets announced
Bringing together protein science, drug discovery experience and innovative technology, a new collaboration aims to identify novel drug targets for COVID-19.
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Self-aligning smart microscope achieves unprecedented resolution
The developers of the ultra-precise single-molecule microscope demonstrated it can resolve interactions between molecules within living cells and is compatible with existing microscopes.
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Fundamental molecular research underpins our ability to combat COVD-19, says article
Ali Shilatifard’s article explains how investment in institutes performing molecular research is essential, as it is the foundation for all attempts to combat COVID-19 and other future pandemics.
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Researchers develop open access database on macrolactones
A group of researchers has created a free library of 14,000 known macrolactones for other scientists to use in drug development.
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VP3 protein: revealing the structure of a potential rotavirus drug target
Researchers hope that by revealing the rotavirus VP3 protein structure and mRNA capping functions, novel antivirals could be designed to prevent or combat rotavirus infections.
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Cervical cancer cell-killing molecule manzamine A found in Indonesian sponge
A study has revealed that a sponge endemic to an Indonesian bay produces manzamine A, a compound which inhibits proteins in cervical cancers.
