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NIH researchers report first 3D structure of DHHC enzymes
The 3D structure of DHHC proteins has been detailed for the first time, explaining how they function and potentially offering a blueprint for designing therapeutic drugs.
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Protein
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Scientists identify potential therapeutic target for HER2-driven breast cancer
Researchers have made a unique discovery about the role of the MED1 protein in breast cancer formation, showing it to be a promising therapeutic target worthy of future study.
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Modified nanoscale virus could deliver peptide drugs to cells
By chipping away at a viral protein, Rice University scientists have discovered a path toward virus-like, nanoscale devices that may be able to deliver drugs to cells.
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Super-silenced DNA study hints at new ways to reprogram cells
Newly described stretches of super-silenced DNA reveal a fresh approach to reprogram cell identity.
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Scientists develop green fluorescent protein to aid intracellular research
Researchers at Osaka University in Japan have developed a superior acid-tolerant green fluorescent protein to enhance the study of intracellular molecular dynamics.
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Application note: Functional GPCR studies using AlphaScreen cAMP Detection Kit
In this application note, PerkinElmer demonstrates the ease and utility of the AlphaScreen® cAMP assay for detecting both agonist and antagonist-induced cAMP responses within cells.
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Thorase protein may be linked to schizophrenia
Epilepsy drug reverses anti-social behaviours in mice with genes that produce variant proteins...
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Application note: Development and utilisation of bromodomain and extra terminal domain (BET) assays using AlphaLISA technology
In this application note, PerkinElmer demonstrates the ease and utility of using AlphaLISA®, a homogeneous assay format, to screen for small molecular inhibitors of BET bromodomains.
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Scientific poster: Developing protein: Protein Interaction (PPI) assays with AlphaLISA and LANCE TR-FRET
In this scientific poster, PerkinElmer demonstrates the ease and utility of using AlphaLISA® and LANCE® TR-FRET homogenous assay forms for studying PPIs.
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F50/T50 combination provides artificial ovary prototype
A protein formulation based on fibrin resembles the architecture and rigidity of human ovarian tissue and could be used for ovary transplant...
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Groundbreaking gene therapy trial set to cure haemophilia
A cure for haemophilia is one step closer, following results of a gene therapy trial led by the NHS in London.
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Application note: Performing NanoBRET with the Varioskan LUX multimode reader
In this paper, Thermo Fisher Scientific aim to assess the performance of Thermo Scientific Varioskan LUX when running NanoBRET.
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Using bioinformatics sequence similarities to optimise repurposing activities
A significant amount of selectivity and potency data originating from screening of drug targets is generated each year and deposited in public databases. This can be exploited to accelerate drug discovery, in particular, for a variety of repurposing activities...
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Q&A: Implementing ADCC assays in QC: when donor variability isn’t an option
DiscoverX recently introduced the single donor-derived KILR CD16 Effector Cells to ensure assay reproducibility for screening, characterisation, and QC lot release of antibody drugs.
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Scientists discover a small molecule that halts kidney disease progression
A team of researchers set out to discover the disease pathways of a rare genetic kidney disease and found a compound that stops the disease in its tracks.
