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Proteomics

Drug Target Review – Issue #4 2017

5 December 2017 | By Drug Target Review

Issue 4 of Drug Target Review looks at artificial intelligence in drug discovery and features In-Depth Focuses on Screening, Hit to Lead and Informatics.

New Alzheimer’s animal model more closely mimics human disease

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New Alzheimer’s animal model more closely mimics human disease

5 December 2017 | By Drug Target Review

Researchers have found that amyloid-? facilitates the interaction between the plaques and abnormal tau.

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DNA mutations shed in blood predicts response to immunotherapy

2 December 2017 | By Dr Zara Kassam (Drug Target Review)

Blood sample, or liquid biopsy, can reveal which patients will respond to checkpoint inhibitor-based immunotherapies...

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RT-QuIC testing detects prion protein in the skin of CJD patients

23 November 2017 | By Dr Zara Kassam (Drug Target Review)

Scientists have detected abnormal prion protein in the skin of patients that have died from Creutzfeldt-Jakob disease...

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Alzheimer’s Tau protein forms toxic complexes with cell membranes

22 November 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers identify the sequence and structural factors that drive Tau interaction with membranes...

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AFM-CRISPR technique used to map DNA mutations

21 November 2017 | By Dr Zara Kassam (Drug Target Review)

Nanomapping technology may transform the way disease-causing genetic mutations are diagnosed and discovered...

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Reducing TIA1 improves nerve cell health in Alzheimer’s disease

20 November 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have described a unique model for the biology of Alzheimer's disease which may lead to an entirely novel approach for treating the disease...

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CXCL5 protein may protect against coronary artery disease

17 November 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have identified a possible genetic basis for coronary artery disease...

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Proteome of the human heart mapped for the first time

15 November 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have compiled an atlas of the heart to identify differences between healthy and diseased cells...

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SORLA protein protects against Alzheimer’s disease

7 November 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have identified a new protective function for a brain protein genetically linked to Alzheimer's...

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CXCR7 receptor reveals potential therapeutic target to reduce brain inflammation

6 November 2017 | By Dr Zara Kassam (Drug Target Review)

CXCR7 receptor identified as a potential therapeutic target for controlling multiple sclerosis, Parkinson's and AIDS...

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Blood test developed to diagnose ovarian cancer

1 November 2017 | By Dr Zara Kassam (Drug Target Review)

Non-invasive diagnostic tool measures circulating microRNAs to predict ovarian cancer with specificity...

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FT4 hormone levels associated with coronary artery disease and death

31 October 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have indicated that high levels of a thyroid hormone FT4, are associated with coronary artery disease...

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Modulating FAP may impede pancreatic cancer

30 October 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers offer a promising target for future therapies that could potentially root out well-hidden metastatic cancer lesions...

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gp120 protein shows promise in HIV vaccine design

30 October 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have developed a vaccine candidate that spurs animals to produce antibodies against protective sugars of multiple HIV strains...

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