news
Chemical synthesis and biological screening combined on chip
Researchers have developed a chip which facilitates and accelerates active substance production, characterisation and biological effectiveness.
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Screening
Medical screening is a strategy used to identify the possible presence of an as-yet-undiagnosed disease in individuals without signs or symptoms.
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Intellicyt iQue3 – Faster, Smarter Flow Cytometry
This advanced flow cytometry platform is a complete instrument, reagents and software solution streamlined to rapidly generate results not just data.
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Video: Ethical and regulatory use of biospecimens in the EU
Unique considerations surrounding the bureaucracy and oversight in the use of human biospecimens in the European Union.
video
Video: Multiplex IHC and digital analysis for immuno-oncology
High content data derived for complex immuno-oncology research facilitates a deeper understanding of the tissue microenvironment.
news
Gene discovery could make cancer therapies more effective
A recent study has identified the DBC1 gene which leaves cancer cells more exposed to therapies.
article
Screening and beyond in drug discovery
Progressing drug discovery projects to a stage that attracts commercial interest is a challenging endeavour, evidenced by the fact that only a small proportion of drug discovery projects are successfully progressed to such a stage. A major cause of this is the lack of comprehensive profiling of compounds prior to…
news
First in vitro lung cancer test launched
A new in vitro lung cancer diagnostic test has been launched by Roche Diagnostics to provide improved detection of cancer.
whitepaper
Application note: Detection of anti-drug antibody (ADA) using single molecule counting (SMCTM) technology
All biological therapeutics have the potential to induce an immunemediated response ranging from benign to severe adverse effects.
news
Researchers identify chemotherapy-enhancing molecule
A new study has found a small molecule which prevents cancer cells from mutating and becoming resistant to chemotherapy.
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Screening In-Depth Focus 2019
This in-depth focus discusses screening and the uses of phenotypic profiling in drug discovery. Also examined is the role that CRISPR/Cas9 gene editing and native mass spectrometry play.
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Phenotypic profiling in drug discovery
Image-based phenotypic profiling of small molecules has been used for identification and characterisation of small molecules in drug discovery and can provide important insights into their mechanisms of action (MOA). This article discusses the use of phenotypic profiling in drug discovery and how machine-learning algorithms could help improve objectivity, processing…
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Drug Target Review – Issue 2 2019
In this issue: novel approaches to produce radiolabelled antibodies, the use of CRISPR/Cas9 to accelerate the development of targeted therapies and utilisation of stem cells to study the effects of cannabis on neuronal development.
news
Autoimmune disorders could be treated with new compounds
New research could lead to novel treatments for autoimmune disorders and sheds light on the causes of autoimmunity.
article
AI-driven automated chemistry as a tool to accelerate drug discovery
Typically, early drug discovery campaigns start with the screening of chemical libraries to identify candidate chemotypes modulating a particular target and/or phenotype. Success of the primary screening depends on multiple factors related to both biology and chemistry. These include the target’s druggability, sensitivity and specificity of assay system, composition and…
