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AI used to diagnose diabetic eye disease
Artificial Intelligence has been used to cost-effectively diagnose diabetic-related eye disease automatically with far more accuracy than current methods...
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Screening
Medical screening is a strategy used to identify the possible presence of an as-yet-undiagnosed disease in individuals without signs or symptoms.
whitepaper
Whitepaper: Application of CRISPR/Cas to the generation of genetically engineered mice
Learn how the continued development of CRISPR gene editing technologies opens fresh possibilities for in vivo model design.
whitepaper
Application note: Rapidly isolate high-producing clones
Find out how to streamline Cell Line Development by identifying high-producing clones with monoclonality assurance in one day.
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Webinar highlights: Harmonising drug-target binding data analytics on a single platform
Harmonising drug-target binding data analytics looks at building a single, integrated software platform for a future pharma research and development digital ecosystem. This webinar, sponsored by PerkinElmer, outlined the fundamentals of a design process where an experimental analytics data workflow was integrated into a more seamlessly interactive digital platform.
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Webinar highlights: Recent advances in diagnostics and treatments – from small molecules to cellular therapies
The webinar presented an overview of the pre-clinical milestones, the current status of the global drug pipeline and a description of a number of novel drugs undergoing clinical trials.
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Immunoassay developed to detect small molecules
An immunoassay developed to analyse small molecules has shown 50 times greater accuracy than current systems of analytical techniques...
news
Pinpointing biopsies to detect and target cancer
Software that overlays tumour information from MRI scans onto ultrasound images could help to highlight areas of concern, and to detect and target cancer...
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Expert view: Challenges in drug discovery screening
The basic premise of drug discovery screening necessitates that the biological assays upon which it depends can be performed in a reproducible manner. In addition, the techniques employed must generate results that are biologically relevant and actionable.
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Webinar highlights: Cell-based and biochemical high-throughput screening in 1536-well plates
The Small Molecule Screening Facility (SMSF) at the University of Wisconsin Madison is a comprehensive high-throughput screening (HTS) centre where researchers have investigated antibiotic-resistant bacterial infections and screening for protein-protein interactions using HTS methods.
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PAINS management: an open source model to eliminate nuisance compounds
High-throughput screening (HTS) technologies have enabled the routine testing of millions of compounds towards the identification of novel ‘hit’ molecules for therapeutic targets. Oftentimes in this drug discovery process, however, compounds that show promising activity in primary screens show no activity during subsequent hit qualification or progression efforts.
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Expert view: Tackling drug discovery inefficiencies requires diverse libraries, technologies with broader applicability and actionable insights
Inefficiencies in drug discovery are hard to ignore when despite ever-increasing investment in pharmaceutical research and development, the number of new drugs approved by the US Food and Drug Administration (FDA) remains low.
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Under the microscope: CROs and microplate reader requirements
Contract Research Organisations rely on microplate readers for effective hit discovery. Ian Waddell, of Charles River Laboratories, explains what his needs are.
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Screening In-Depth Focus 2018
This In-Depth Focus looks at a high-throughput approach for measuring intracellular ATP levels to access compound-mediated cellular toxicity, the role of drug transporters in phenotypic screening, and how to leverage the power of HTS in the new and rapidly evolving collaborative drug discovery landscape.
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High-resolution magnetic resonance imaging using less contrast medium
A lower quantity of contrast protein, in comparison to current methods, has obtained clear, high-resolution images from magnetic resonance imaging...
