Toxicology

Eppendorf

Whitepaper: Opportunities in preclinical development

11 July 2018 | By IDBS

This whitepaper explains how you can find ways to optimise the holistic preclinical development process...

Genomics in drug development and safety testing; from target identification to genomic toxicology

3 July 2018 | By Adam David Thomas

In the annual report of the Chief Medical Officer, 1 Dame Sally Davies has declared that we are part of ‘generation genome’ – the era in which we reap the rewards of our advances in genomic technologies and improvements in our understanding of the whole genome in human health.

SMi’s 13th Annual ADMET conference 2018 brochure released

17 April 2018 | By SMi Group

The annual ADMET conference is returning to London, UK for its 13th year running and will be taking place at the Holiday Inn Kensington Forum on the 9 and 10 July 2018...

Expert view: Conquering late stage failures with advanced hit-to-lead techniques

14 December 2017 | By Steven G Jarvis (Head of Pharma & Biotech Segment Strategy - MilliporeSigma)

Failing early in drug discovery is the primary driving force for new techniques in the hit-to-lead phase.

Identification of hits and leads for human African trypanosomiasis

13 December 2017 | By Dr Sheraz Gul, Giulia Pasini, Maria Paola Costi

Neglected tropical diseases (NTD) affect more than one billion people and new targets and drugs are needed to tackle these infections. The multi-disciplinary NMTrypI consortium has identified a number of different compound classes which could be effective against these diseases. This article reviews some of these compounds...

Prenatal exposure to BPA at low levels can affect gene expression

1 November 2017 | By Dr Zara Kassam (Drug Target Review)

Prenatal exposure to BPA affects gene expression related to sexual differentiation and neurodevelopment in the developing brain...

New botulinum neurotoxin discovered

3 August 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have identified a new toxin, botulinum neurotoxin type X (BoNT/X), that has the potential to open up a new field of toxin therapeutics...

Balance and movement improved in animal model of Parkinson’s disease

12 June 2017 | By Niamh Marriott (Drug Target Review)

Researchers have developed a molecular compound that improves balance and coordination in mice with early stage Parkinson's disease.

The mast cell receptor MrgX2 and drug-induced anaphylaxis

10 May 2017 | By DiscoverX

The goal of this webinar is to illustrate how knowledge of MrgX2 activity across a panel of mammalian species can be integrated into drug development to influence choice of compound, species model and dosing regimen...

Novel method to detect toxic effects of chemicals could reduce need for animal testing

25 April 2017 | By Niamh Marriott (Drug Target Review)

Traditional toxicological investigations performed on animals (in vivo) are expensive, time-consuming and may cause animal suffering.

Sound Pharmaceuticals receives $1.6 Million Award to treat CF-related tinnitus

22 March 2017 | By Niamh Marriott (Drug Target Review)

Sound Pharmaceuticals has been awarded up to $1.6M from Cystic Fibrosis Foundation Therapeutics (CFFT), the non-profit drug discovery and development affiliate of the Cystic Fibrosis Foundation.

StemTek and tebu-bio announce European partnership for Cell2Sphere

19 January 2017 | By Niamh Marriott (Drug Target Review)

Cell2Sphere is the first simple 3D tissue culture kit for labs interested in more accurate, scalable and dynamic experimental research.

Benzodiazepines increase stroke risk in Alzheimer’s patients

16 January 2017 | By Niamh Marriott (Drug Target Review)

The use of benzodiazepines and benzodiazepine-like drugs was associated with a 20% increased risk of stroke among persons with Alzheimer’s disease, shows a recent study from the University of Eastern Finland.

Advancing non-animal testing methods: EC publishes tool guidance

30 September 2016 | By Niamh Louise Marriott, Digital Content Producer

The AOPs are knowledge management tools in toxicology and are useful for supporting risk assessment to human health and to increase non-animal testing...