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Blood-brain barrier role in Alzheimer’s patients revealed by tissue model
A new study has found that damage caused by Alzheimer's allows toxins to enter the brain, further harming neurons.
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Encouraging drug discovery and therapeutic targets for dementia
A review has been published by experts in neurodegeneration research, detailing six ways to improve dementia research. This article investigates one of these suggestions, focusing on how we can improve drug target identification.
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Crystals mapped to advance treatments for stroke, diabetes and dementia
Researchers haved mapped the crystal structure of a protein to find out how a drug latches onto it.
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Potential drug target for Alzheimer’s identified
New research has identified an enzyme which causes degradation of dendritic spines, pointing to a drug target for Alzheimer’s.
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Neurofilament light chains detect Alzheimer’s damage before symptoms
A simple blood test reliably detects signs of brain damage in people on the path to developing Alzheimer's disease...
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Nuclear tracers help assess new drugs for neurodegenerative diseases
New nuclear medicine tracers could help medical researchers find a cure for Alzheimer's and other neurodegenerative diseases.
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New tools accurately illuminates intracellular phase separation
Researchers have made discoveries about the formation of cellular components called membraneless organelles and the key role these organelles play in cells...
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MRI scans shows promise in predicting dementia
Brain changes evident in scans before memory, cognitive decline...
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New information on the pathological mechanisms of Alzheimer’s disease
Researchers have indicated that the accumulation of pathological tau triggers a safety valve mechanism in the otherwise well-regulated cell membranes...
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Protein sequencing method could transform biological research
A team of researchers have demonstrated a new way to sequence proteins that are much more sensitive than existing technology, identifying individual protein molecules rather than requiring millions of molecules at a time
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Immunotherapy targeting blood protein fibrin
Targeting the fibrin protein could ensure that fibrin leaking through the blood-brain barrier does not cause inflammation or disease in the brain...
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Scientists create map of brain region linked to Alzheimer’s disease
Scientists have mapped areas of the brain that are linked to Alzheimer's disease to deliver genetically-targeted drugs to specific neurons...
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Cryo-EM shows structure of TRPM2
The structure of the protein TRPM2, a possible drug target, has been revealed for the first time by researchers at Van Andel Research Institute...
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The molecular link between ageing and neurodegeneration
Researchers have described the discovery of a molecular link between ageing and a major genetic cause of both ALS and FTD...
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Study suggests viral connection to Alzheimer’s disease
A first-of-its-kind study implicates another culprit in the path to Alzheimer's disease: the presence of viruses in the brain...