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Grant to fund development of vaccines to prevent dementia
Researchers at Washington University are developing a vaccine using nanofiber technology to prevent dementia, offering a safer and more effective alternative to current treatments.
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frontotemporal dementia (FTD)
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KCNJ2 inhibition: a therapeutic target for traumatic brain injury
Using cortical organoids, researchers discovered that targeting KCNJ2 could reduce nerve cell death after TBI.
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Exploring the conditions in which pathological 4R tau misfolds
Researchers have presented new findings that offer potential pathways to arrest critical steps toward the accumulation of mutant tau.
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New cell culture model reveals neurodegeneration mechanisms
Researchers discovered that NPTX2 protein accumulated in cells containing abnormal TDP-43 in FTD and ALS patients.
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Neurodevelopmental defects seen in mini-brains with ANG mutation
Researchers found that ANG in its mutated form slows stem cell differentiation, resulting in neurodevelopmental defects in adult nerve cells.
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Huntington’s disease: danger of repeated DNA sequences
Scientists find a way to slow the progression of Huntington’s disease by analysing DNA and find the basis of a potential treatment.
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Huntington’s disease: a way to prevent cognitive decline
Discovery about Huntington’s disease may apply to other neurodegenerative disorders, like Alzheimer’s and frontotemporal dementia.
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A Molecular Portrait of ALS and FTD
In the sections that follow, we dive in on the latest research describing the underlying causes of ALS and a closely related condition known as frontotemporal dementia (FTD), two forms of neurodegenerative disease that share striking similarities in their molecular pathologies.
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Molecular pathway shared by two neurodegenerative disorders found
Scientists have gained deeper knowledge about the mislocalisation of a protein, providing a possible therapeutic target that could have implications in treating dementia.
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Understanding the tau tangles in neurodegeneration could aid treatment discovery
Representing a breakthrough in better understanding how tau proteins cause neurodegenerative disease, scientists have mapped the tau interactome.
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New Oxford-GSK Institute aims to unravel complex diseases
GlaxoSmithKline (GSK) and the University of Oxford will collaborate to investigate diseases using technologies such as functional genomics and machine learning.
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Scientists target ALS and dementia RNA using novel molecule
The small molecule successfully targeted the C9orf72 gene that causes amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
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Getting “under the skin” of frontotemporal dementia
Researchers at the University of East Finland have been using skin cells to investigate pathological hallmarks in frontotemporal dementia patients.
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How engineered RNA binding proteins delivered in vivo by gene therapy could treat myotonic dystrophy
In this article, Dr Jim Burns discusses promising pre-clinical results of how a new platform could treat the root cause of many devastating genetic diseases including myotonic dystrophy type 1.
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Researchers identify a novel tau aggregation control mechanism
According to researchers, the more small tau protein variants expressed by neurons, the slower neurofibrillary tangles form.
