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Novel protein coordinates melanin production
Japanese researchers reported that a key transcription factor “Nrf3” regulates the process of melanin production in mouse and human cells.
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Melanoma
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Synthetic biology is ready for the therapeutic limelight
After initially serving as a proving ground for integrating forward engineering principles into living cells, synthetic biology is making waves across diverse therapeutic areas. In this article, Dr Dan Mandell, Co-Founder and CEO of GRO Biosciences, explains how the field is reshaping our understanding of the limits of cell- and molecular-based medicines.
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Whole exome sequencing predicts whether cancer patients will respond to immunotherapy
Researchers have developed a two-step approach using whole exome sequencing to focus on genes and pathways that predict whether cancer patients will respond to immunotherapy.
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Using immunotherapy to prevent cancer metastases
Scientists have demonstrated how killer T cells used in immunotherapy to eliminate cancer cells can also destroy tumour lymphatic vessels, thus greatly reducing the risk of metastasis.
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Biodegradable gel boosts immune system’s attack on several cancers in mice
A new biodegradable gel can release drugs and special antibodies that simultaneously deplete macrophages from the surgical site and activate T cells.
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Triggering ferroptosis in cancer cells
A new study from the University of Michigan Rogel Cancer Center, US has revealed that a cytokine and a fatty acid can work together to trigger ferroptosis. Here, Dr Weiping Zou, the lead researcher from the study, outlines how this process could be used to target cancer cells and enhance immunotherapies.
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Nanotechnology boosts immune response at tumour site in mice
The new nanotechnology left six of 10 mice with lymphoma tumour-free and was effective in melanoma when combined with existing drugs.
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Targeting channel in cell lysosome could selectively kill cancer cells
Activating the protein channel TRPML1 induced selective melanoma cell death while sparing normal cells, suggesting a potential pathway for new cancer therapies.
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New nanotechnology could combat colorectal cancer and melanoma
A nanotherapeutic delivery system displayed high efficacy against metastatic tumours in mice, potentially improving chemotherapy treatments.
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Sunlight shown to trigger DNA mutation that causes melanoma
New research found mutations that cause melanoma result from a chemical conversion in DNA fuelled by sunlight, undermining previous theories.
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Natural killer cell immunotherapy shows promise against melanoma
Researchers have shown that natural killer cell immunotherapy effectively treated mice harbouring human melanoma tumours.
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Team identifies potential drug to repurpose against melanoma
Researchers say that inhibiting NLRP3 with Dapansutrile could be an effective strategy to prevent melanoma tumour growth.
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Tumour cell vaccine strategy developed for neuroblastoma and melanoma
A combination of checkpoint and small molecule inhibitors showed success at targeting Myc oncogenes in mouse neuroblastoma and melanoma models.
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NOX5: a novel target for sensitising melanoma to therapies
Vito Quaranta, professor of biochemistry and pharmacology, discusses how cancerous cells adopting novel mechanisms of energy production could be sensitised to existing therapies with a focus on melanoma.
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Immunotherapy with radiotherapy could improve outcomes of cancers in liver
Researchers have discovered that in mice with cancers in the liver, immunotherapy and radiotherapy prevented T-cell death.
