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Targeting zombie cells: a new treatment for chronic back pain
McGill University researchers have found that two drugs can eliminate senescent “zombie cells” in spinal discs, offering a potential new treatment for chronic low back pain.
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Osteoporosis
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New method of designing drugs without side effects
Japanese researchers now reveal a new way of activating GPCR by triggering shape changes in the intracellular region of the receptor. This new process can help researchers design drugs with fewer or no side effects.
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New screening technique to accelerate the discovery of cancer-fighting drugs
The novel screening technique can identify molecules that can disable dangerous proteins before they cause diseases by blocking them from interacting with a cell’s DNA.
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Promising target for osteoporosis treatments found in new study
By identifying a mechanism behind bone strengthening in response to stress, researchers have found a possible new target for treating conditions that weaken bones.
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Genetic profile of skeleton osteocytes mapped for first time
Researchers have revealed which genes are switched on or off in osteocytes, a bone cell found in the skeleton.
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MALP cells as a potential target for osteoporosis drug development
Researchers have found that bone marrow adipogenic lineage precursor (MALP) cells may initiate the production of osteoclasts and drive bone remodelling in osteoporosis.
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Novel biomaterial could be used to accelerate bone regeneration
In lab conditions, a new biomaterial was able to accelerate bone regeneration by boosting an immune response that encourages repair.
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The growing possibilities for stem cells in pharma
Drug Target Review explores the latest applications of stem cells in modelling disease, drug production and the most recent steps in regenerative medicine provided by research.
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Activating bone stem cells has potential therapeutic applications
A study has demonstrated that activating bone periosteal stem cells leads to increased bone healing in mice, presenting a potential therapeutic strategy.
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Osteoporosis in mice reversed with new drug target
A pharmaceutical target has been identified by Duke University that, when activated, can reverse bone degradation caused by osteoporosis.
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Small molecule factors found to influence age-related bone deterioration
Scientists in the U.S. have reported findings about the mechanisms that contribute to the experience of weaker bones with age.
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Removing old cells could extend joint health & stop osteoarthritis
In a preclinical study in mice and human cells, researchers report that selectively removing old or 'senescent' cells from joints could stop and even reverse the progression of osteoarthritis.
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Regenerating bone and cartilage tissues from apple waste
Researchers from UPM and CSIC have employed waste from the agri-food industry to develop biomaterials that are able to act as matrices to regenerate bone and cartilage tissues, which is of great interest for the treatment of diseases related to ageing.
