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Single-cell approach generates RNA atlas of breast cancer tissue
Researchers have measured the gene expression of healthy and cancerous single cells from breast tissue, creating an 'RNA atlas'.
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Microfluidic screening reveals SARS-CoV-2 antibody candidate
Microfluidic screening technologies have been used to discover a promising antibody candidate against SARS-CoV-2 and the South African variant.
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New mouse model could be used to develop better HIV treatments
A new pre-clinical mouse model could enable the study of HIV infection and the testing of cell therapies against the virus.
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Lipid droplets may prevent kidney damage from high-fat diets
Researchers have shown in fruit flies that lipid droplets could prevent the kidney damage that leads to chronic kidney disease.
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Natural killer cells and bispecific antibody target lymphoma tumours
In pre-clinical studies, researchers showed that cord blood-derived natural killer cells and a bispecific antibody eliminated lymphoma cells.
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Automated method to produce synthetic DNA created
Researchers have developed a technique to synthetically produce DNA oligonucleotides that avoids the degradation of phosphoramidites.
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New vaccine design developed to protect against Ebola virus
Researchers have designed a new nanoparticle-based vaccine against Ebola that has shown promise in mice and rabbits.
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Five of the latest developments in 3D bioprinting
Drug Target Review brings you five of the most recent developments in three-dimensional (3D) bioprinting.
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Novel CRISPR strategy developed for Duchenne muscular dystrophy
A CRISPR gene editing technique has been developed to restore dystrophin, which is missing in many Duchenne muscular dystrophy (DMD) patients.
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New vaccine protects against COVID-19 and variants in pre-clinical studies
A new vaccine has shown promise at protecting monkeys and mice from COVID-19, its variants and other coronaviruses.
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Single-cell map of lung cancer sheds light on tumour development
A spatial atlas of early-stage lung cancer has been compiled at single-cell resolution, revealing new therapeutic targets.
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Researchers make key discovery involved in re-engineering of peptides
A team has characterised a key part of the peptide synthesis process, showing that only the main building block needs to be changed for re-engineering.
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Second mechanism of action discovered for COVID-19 drug remdesivir
Researchers have found that a metabolite of remdesivir potentially targets a SARS-CoV-2 protein involved in suppressing the host cell's defence response.
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Structure of DNA actively involved in genome regulation, study shows
Researchers have shown that topoisomerase TOP2A eliminates negative supercoiling, causing an increase in the number of turns of DNA strands and impacting gene expression.
