A faster and stronger rabies vaccine has been developed
A new rabies vaccine strategy enhanced the speed and magnitude of the anti-rabies antibody responses and could improve the efficacy of currently used vaccines.
Researchers have reported that adding a specific immune molecule to a rabies vaccine can boost its efficacy.
Previous studies have suggested that the existing rabies vaccine (which is costly and complicated to administer) works by activating the immune system’s B cells. However it can take time for the vaccine, which contains inactivated virus particles, to interact with the B cells.
James McGettigan from Thomas Jefferson University, USA, and colleagues have now turned to a signalling protein known as B cell activating factor (BAFF), which binds directly to B cells. They designed a rabies vaccine which included an attenuated rabies virus and BAFF on the same particle, hoping to target the vaccine directly to B cells for activation. Then they tested the new vaccine in mice.
Mice immunised with the BAFF-enhanced rabies vaccine showed a faster and stronger response of the immune system compared to animals that received the typical vaccine. Levels of virus neutralising antibodies increased more quickly and to higher levels. However, the duration of the response was not affected and additional studies on the safety of the vaccine are needed before testing it in humans.
“This new vaccine strategy significantly enhanced the speed and magnitude of the anti-rabies antibody responses and has the potential to improve the efficacy of currently used inactivated RABV-based vaccines,” the researchers said.
The research was published in PLOS Neglected Tropical Diseases.