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The potential of PD-L2 inhibitors for cancer treatment
Researchers discover that blocking PD-L2 in senescent cells increases the efficacy of chemotherapy in mouse models.
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Institute for Research in Biomedicine (IRB Barcelona)
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Unexpected patterns in DNA mutations identified
Disruptions in TP53 and RB1 are key influencers that cause changes in the risk of mutations across chromosomes.
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Researchers find that CRISPR gene editing can give rise to cell toxicity and genomic instability
Using computational methods, researchers analysed the most popular CRISPR library designed for human cells and found 3,300 targeted spots that show strong toxic effects.
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HAT proteins could unveil new cancer and Alzheimer’s treatments
The new study used cryo-electron microscopy to visualise the structure of a HAT protein and uncover compounds for drug development.
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Bioactivity information of one million molecules compiled
Using deep machine learning, researchers have completed the activity profiles, from chemistry to clinical level, for one million molecules.
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Regulating cell plasticity through CDK8 inhibition
Researchers show CDK8 inhibition reduces cell plasticity without damaging cells and suggest their approach could have implications for autoimmunity and oncology.
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Researchers identify over 550 cancer-driving genes
Computational analysis has been used by researchers to examine 66 types of cancer and identify 568 genes that drive tumour development.
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Genes responsible for gender differences in tumours identified
A new study has identified possible regulators that determine differences in cancer tumours between genders.
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Study shows p38 protein regulates formation of new blood vessels
A new study shows that the activity of p38 is important in MSCs, which can localise around blood vessels.
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Scientists achieve the first stable simulations of DNA crystals
A study by researchers at the Institute for Research in Biomedicine has been the first to achieve stable simulations of DNA crystals...
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EXD2 enzyme identified as key player in mitochondrial protein synthesis
A team of researchers led by IRB Barcelona in Spain have identified a key function of the enzyme EXD2 as being the maintenance of protein production in the mitochondria.
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Discovery into cells’ energy supply could lead to targeted cancer treatment
Scientists have made a significant breakthrough in understanding how the molecular machines that produce key proteins are cleaned and maintained. ..