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TSRI’s rat study shows how brain stores memories
A new study led by scientists at the Scripps Research Institute (TSRI) sheds light on how the brain stores memories.
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National Institutes of Health (NIH)
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Next-Generation Sequencing In-Depth Focus 2016
NGS technologies have been employed in a wide range of areas in drug discovery, including drug target identification, biomarker discovery and biopharmaceutics development. Pushpanathan Muthuirulan of the National Institutes of Health gives us an overview of this in his article in our NGS In-Depth Focus. Meanwhile, the possibilities that RNA-Seq…
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TSRI scientists develop vaccine against fatal prescription opioid overdose
30 November 2016 | By Niamh Louise Marriott, Digital Editor
Scientists at The Scripps Research Institute have developed a vaccine that blocks the pain-numbing effects of the opioid drugs in animal models...
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AiCuris’ preclinical Hepatitis B study gains NIH support
28 November 2016 | By Niamh Louise Marriott, Digital Editor
This preclinical study should explore the potential of AIC649 to cure infections caused by hepatitis B virus (HBV) and is investigating the efficacy...
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Flow cytometry: breaking bottlenecks in drug discovery and development
The discovery and development of novel drug candidates is a highly complex, time-consuming and expensive process. Pharmaceutical scientists and clinicians should, therefore, reevaluate and modify the existing standard platforms and increase their uptake of robust advanced technologies such as flow cytometry to overcome the bottlenecks in these processes...
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Novel inhibitory brain receptor puts epilepsy in remission at adolescence
26 August 2016 | By Niamh Louise Marriott, Digital Content Producer
At the onset of puberty, the emergence of a novel inhibitory brain receptor, α4βδ (alpha four beta delta), reduces epilepsy seizure-like activity in mouse...
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NIH to research health disparities of chronic diseases
25 August 2016 | By Niamh Louise Marriott, Digital Content Producer
This program responds to the need for more robust, ecological approaches to address chronic diseases among racial and ethnic minority groups, under-served rural populations, people of less privileged socio-economic status, along with groups subject to discrimination who have poorer health outcomes often attributed to being socially disadvantaged...
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Depression genes found by tapping crowd-sourced data
4 August 2016 | By National Institute of Health (NIH)
Scientists have discovered 15 genome sites — the first ever — linked to depression in people of European ancestry. Many of these regions of depression-linked genetic variation turn out to be involved in regulating gene expression and the birth of new neurons in the developing brain...
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Inducing antibodies could lead to a universal flu vaccine
25 July 2016 | By Niamh Louise Marriott, Digital Content Producer
Scientists have identified three types of vaccine-induced antibodies that can neutralise diverse strains of the flu virus that infect so many each year...
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NIH funds six research collaborations to find a cure for HIV
14 July 2016 | By Victoria White, Digital Content Producer
The US National Institutes of Health has awarded $30 million in annual funding to help advance science towards a cure for HIV...
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Researchers to monitor potential Zira virus exposure in US Olympic team
5 July 2016 | By Victoria White, Digital Content Producer
The study aims to improve understanding of how the Zika virus persists in the body and to identify potential factors that influence the course of infection...
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Anthrax toxin protein regimen shows promise in treating cancerous tumours
28 June 2016 | By Victoria White, Digital Content Producer
Combining engineered anthrax toxin proteins and existing chemotherapy drugs could potentially yield a therapy to reduce or eliminate cancerous tumours...
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International Zika study to enrol 10,000 pregnant women
21 June 2016 | By Victoria White, Digital Content Producer
NIH and Fiocruz have begun a study to evaluate the health risks that Zika virus infection poses to pregnant women and their developing foetuses...
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Boosting mitochondria may help regenerate damaged neurons
8 June 2016 | By Victoria White, Digital Content Producer
Researchers have discovered that boosting the transport of mitochondria along neuronal axons enhances the ability of nerve cells to repair themselves...
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Potentially revolutionary antidepressant compound discovered
4 May 2016 | By Victoria White, Digital Content Producer
Researchers have identified a metabolite of ketamine, hydroxynorketamine, that quickly reverses depression in mice, but without ketamine's side effects...
