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Chemokines work undercover as drivers of autoimmune disease
New research has uncovered a hitherto unknown mechanism whereby chemokines form DNA-bound nanoparticles that play a key role in autoimmune disorders.
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Weill Cornell Medicine
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Whole exome sequencing predicts whether cancer patients will respond to immunotherapy
Researchers have developed a two-step approach using whole exome sequencing to focus on genes and pathways that predict whether cancer patients will respond to immunotherapy.
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IgG antibodies in breast milk help shape infants’ gut bacteria and immunity
A new study in mice has highlighted that gut beneficial bacteria can be transferred from mothers to infants through breast milk and help infants defend against infection-induced diarrheal illness.
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New prostate cancer subtype may illuminate treatment strategy
Researchers have identified a previously unrecognised form of hormone therapy-resistant prostate cancer.
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Enzyme revealed as promising new target for cancer immunotherapies
A new study has highlighted an enzyme called ART1 as a promising target for immunity-boosting cancer treatments.
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Antibody drug target identified for influenza viruses
Researchers have found a small subset of antibodies that target a site at the base of the influenza virus hemagglutinin protein.
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Two COVID-19 vaccines show safety and strong immunity in infant model
Two groups of infant rhesus macaques received one of two potential COVID-19 vaccines, which were shown to elicit high levels of neutralising antibodies.
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New mouse model could be used to develop better HIV treatments
A new pre-clinical mouse model could enable the study of HIV infection and the testing of cell therapies against the virus.
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Novel technique provides detailed map of lung pathology in COVID-19
Researchers have used imaging mass cytometry to analyse the cellular landscape of diseased lung tissue in severe COVID-19, revealing insights into the disease.
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Study shows that FOXO3 gene protects brain stem cells
A version of the FOXO3 gene can protect brain stem cells from stress during ageing, according to a new study.
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Flaw found in lab models used to study human blood-brain barrier
Researchers have uncovered a flaw in lab models used to study the human blood-brain barrier and a potential strategy to correct the error.
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Ion channel ball-and-chain mechanism imaged after decades of attempts
Scientists have imaged the ball-and-chain mechanism using cryogenic electron microscopy and hope their work could be applied in the design of novel therapeutics.
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Mechanism behind Piezo proteins discovered using imaging technique
A new study has used a combination of imaging methods to understand how the Piezo protein works, improving research into treatments for conditions such as high blood pressure.
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Cancer vaccine shows promising results in Lynch syndrome
Vaccination with as few as four tumour antigens generated antigen-specific responses, reduced intestinal tumours, and improved survival in a mouse model of Lynch syndrome...
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Avenue discovered for precision cancer treatment
A novel chemical dubbed "T-REX," along with a patent-pending targeting molecule have uncovered interesting facets of several well-known cancer-cell mutations that, if present in a patient, could inform treatment options and potentially produce more favourable outcomes...
