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Scientists have discovered important redundancies in T cells
Redundancies have been discovered in the biochemical signalling pathways of immune cells which could impact cancer immunotherapy.
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Antibodies
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Protective antibodies identified that could be key to malaria vaccine
A new study has identified antibodies that may hold the key to creating the first effective vaccine against malaria infection in the blood.
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Antibody treatment allows mismatched stem cell transplant in mice
New study finds a combination of antibodies that can prepare mice to accept stem cells from an immunologically mismatched donor.
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Image-based characterisation of cancer biotherapeutics
Scientists from LifeArc, an independent medical research charity in the UK, explain how they’re using the latest imaging technologies to progress drug discovery campaigns and identify the most promising candidates for antibody-based therapies.
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Radiochemistry and drug synthesis ‘in a flash’
Conventional methods for radiolabelling proteins are time consuming and difficult to automate. In this article, Jason P. Holland discusses how combining photochemistry with radiochemistry enables development of radiolabelled proteins far more quickly and easily – literally in a flash of light.
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Drug Target Review – Issue 2 2019
In this issue: novel approaches to produce radiolabelled antibodies, the use of CRISPR/Cas9 to accelerate the development of targeted therapies and utilisation of stem cells to study the effects of cannabis on neuronal development.
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New study brings universal flu vaccine a step closer
An international team of researchers has proven that targeting a specific area of the flu virus protects humans.
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Hidden influenza vulnerability found in human antibodies
Scientists have discovered an unexpected weakness in the influenza virus protein.
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‘Inconsistent’ use of antibodies found in laboratory experiments
16 May 2019 | By
Researchers say they have affirmed inconsistencies in the use of a common laboratory procedure called immunohistochemical staining.
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Squaring the circle – cancer vaccines
By the 1890s William B. Coley had injected streptococcal organisms in patients with solid tumours (“Coley’s Toxins”) to activate the immune system. Coley (1862-1936) was an American bone surgeon and pioneer of cancer immunotherapy. He was convinced that post-surgical infections had helped patients to recover better from their cancer by…
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Key step in the transformation of B-cells to antibody-secreting cells described
Scientists have detailed the role of a key controlling factor in the transformation of B-cells into antibody-secreting cells.
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Method for radiolabelling antibodies against breast cancer developed
Researchers from the University of Zurich have created a new method for radiolabelling antibodies using UV light - with proteins being ready-to-use for cancer imaging or therapy in less than 15 minutes.
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Human antibody discovery could save lives from fungal killer
Novel therapy uses antibodies cloned from patients who have recovered from an infection caused by the fungus Candida…
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Application note: A novel solution to expedite antibody discovery
With breakthroughs in molecular engineering and antibody humanisation, monoclonal antibodies (mAb) are one of the fastest-growing classes of biopharmaceuticals for multiple clinical indications including cancer, cardiovascular disease, autoimmune disorders and infectious disease. Most therapeutic antibody candidates are initially generated using hybridoma technology or primary B-cell screening after antigen immunisation.
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Charles River Laboratories continues commitment to oncology drug discovery
Team of oncology experts expand data in Tumor Model Compendium and present strong portfolio at industry conferences...
