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Drug Target Review – Issue #1 2017
Included in this issue: Importance of building patient trust; Vaccines & Immunology; Oncology; Assays; Biomarkers; and Antibodies...
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Assays
An assay is an analytical procedure in laboratory medicine, pharmacology and molecular biology for measuring the activity of a target entity.
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Whole animal screening: back to the future
High throughput screening (HTS) has become an integral and productive part of early-stage drug discovery, delivering hits that were the starting points for hit-to-lead programmes and resulting in a number of marketed drugs. HTS can be carried out in a number of formats, ranging from simple biochemical (target-based) to whole…
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Product Hub: Flow cytometric screening assays in drug discovery
Flow cytometry is a laser-based technology – a powerful tool for drug discovery and the screening process and can be used in all settings, including research, clinical, pharmaceutical and biotechnology. The increasing capabilities of flow cytometers make their incorporation into drug development and screening optimal...
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Booklet: InCELL Pulse™ Target Engagement Kinase Reference Set
Monitoring cellular drug permeability and target engagement enables assessment of compound efficacy and confirmation of mode of action. InCELL Pulse target engagement assays provide the ability to confirm compound cell entry and target engagement while overcoming limitations of current target engagement assays...
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StemTek and tebu-bio announce European partnership for Cell2Sphere
Cell2Sphere is the first simple 3D tissue culture kit for labs interested in more accurate, scalable and dynamic experimental research.
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Application Note: An Easy-to-Use Assay to Measure Target Cell Death by Antibody Dependent Cellular Phagocytosis (ADCP)
With an increasing industry focus on antibody drugs, there is an ever greater need for functional bioassays that interrogate the various mechanisms of action (MOA) for the therapeutic antibody...
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IDBS launches E-WorkBook Cloud to manage scientific and R&D data
IDBS has launched the E-WorkBook Cloud, an enterprise, Cloud-based platform designed specifically to meet the future challenges of scientific and R&D data management.
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ProteinSimple Milo
12 January 2017 | By ProteinSimple
Single-Cell Western system capable of analysing protein expression in ~1,000 single-cells in parallel to unlock heterogeneity...
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High-throughput screening platforms incorporating physiologically relevant 3-D models
Two-dimensional monolayer cell proliferation assays for cancer drug discovery have enabled large-scale screens. But they represent a simplified view of oncogenes or tumour suppressor genes as the genetic drivers of cancer cell proliferation.
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DiscoverX HitHunter® cAMP Assays
21 December 2016 | By DiscoverX Corporations
Optimized Assays for a Multitude of GPCR Applications...
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DiscoverX SAFETYscan™ In Vitro Pharmacological Profiling Services
21 December 2016 | By DiscoverX Corporation
Designed for lead optimisation and safety profiling, DiscoverX’s SAFETYscan in vitro pharmacological profiling services improve off-target liability testing...
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PathHunter® Protein Translocation Assays
21 December 2016 | By DiscoverX Corporation
The movement of proteins between cellular compartments is essential for their specific biological role and the function of the cell...
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Screening In-Depth Focus 2016
In this Screening In-Depth Focus, scientists from the Assay Development and Screening Platform of Helmholtz Zentrum München provide an overview of different high-throughput screening (HTS)-applicable assay types that can be applied to drug discovery campaigns. Plus an interview with Lee Babiss, CEO of drug discovery firm X-Rx, on the benefits…
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App Note: Determination of antioxidant capacity on the Thermo Scientific Varioskan LUX Multimode Reader
This application note describes a method to measure the ORAC of different food and beverage samples with a fluorometric assay...
