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Source of nucleic-acid asymmetry could improve gene therapies
Researchers have analysed the physical origin and biological consequences of DNA-RNA hybrids which could inform gene therapies.
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New technology provides process for precise gene editing
Researchers have presented their new technology for accurately inserting genes into the genome without cutting DNA.
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Autoimmune disorders could be treated with new compounds
New research could lead to novel treatments for autoimmune disorders and sheds light on the causes of autoimmunity.
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DNA nanostructures for drug delivery remain a technical challenge
Many studies indicating that DNA nanostructures can enter cells more readily than simple DNA strands are 'flawed'.
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Colon cancer proteins and gene analysis uncovers potential new treatments
A new study analysing both the entire set of genes and all the proteins produced by colon cancer tissues has revealed a more comprehensive view of the tumour.
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Cancer-killing combination therapies unveiled with new drug-screening tool
Method IDs which target therapies, inadequately on their own, can be paired up to kill non-responsive cancers...
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Realising the promise of laboratory automation in biomedical research
Automation offers a choice of powerful ways to design and execute high-quality laboratory research. The use of lab automation is now pervasive in biomedical labs, offering versatile platforms on which to perform an ever‑expanding array of tasks free of human errors, and a unique means to address the problems associated…
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New DNA ‘shredder’ technique goes beyond CRISPR’s scissors
A new CRISPR-based tool that acts more like a shredder is able to wipe out long stretches of DNA in human cells with programmable targeting...
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CRISPR-Chip enables digital detection of DNA without amplification
Researchers have found multiple applications for the CRISPR (Clustered Regularly Interspersed Short Palindromic Repeats) gene editing technology since it came into use by the scientific community...
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Scientists find a cellular process that stops cancer before it starts
Salk research shows that cellular recycling process, thought to fuel cancer's growth, can actually prevent it...
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Scientists achieve the first stable simulations of DNA crystals
A study by researchers at the Institute for Research in Biomedicine has been the first to achieve stable simulations of DNA crystals...
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Molecules associated with NMDAR may be involved in schizophrenia
Genetic variants which prevent a neurotransmitter receptor from working properly have been implicated in the development of schizophrenia...
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DNA barcodes that reliably work: A game-changer for biomedical research
A new method for correcting the errors that creep into DNA barcodes has paved the way for more ambitious medical research...
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Omics-informed drug target discovery in combating emerging infectious diseases
The catastrophic consequences of ever-increasing rates of death from infectious diseases demands new experimental strategies for drug target selection and drug design. Over the last decade, the pharmaceutical industry has been wounded by several issues including failure of drug-development programmes, burgeoning cost of drug development, increasing regulatory control, lack of…
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T-cells engineered to recognise tumours expressing the CD30 protein marker
Researchers have genetically engineered immune cells to recognise and fight Hodgkin and non-Hodgkin lymphoma cells...
